Synchronous multiple primary cancers involving cervical cancer and follicular lymphoma: A case report.

Multiple primary cancers refers to the occurrence of two or more histologically distinct tumor types, either simultaneously or sequentially. The present report describes a rare case of a 46-year-old female patient simultaneously diagnosed with cervical cancer and low-grade follicular lymphoma (FL). The patient presented with vaginal bleeding and a subsequent cervical biopsy confirmed cervical squamous cell carcinoma.

Malignant glomus tumor of jejunum with liver and peritoneum metastasis: a rare case report.

Glomus tumors (GTs) are rare mesenchymal neoplasms that occur predominantly on the subungual region of the distal extremities and are rarely seen in visceral organs such as the gastrointestinal tract. Malignant glomus tumors (MGTs) is even more rare, comprising less than 1% of all GTs. We reported an 82-year-old female patient with MGTs of the jejunum, accompanied by metastases to the liver and peritoneum.

Identification and Validation of Epithelial Cell Centre Regulatory Transcription Factors in the Gastric Cancer Microenvironment.

Purpose: To identify the epithelial cell centre regulatory transcription factors in the gastric cancer (GC) microenvironment and provide a new strategy for the diagnosis and treatment of GC.

Methods: The GC single-cell dataset was downloaded from the Gene Expression Omnibus (GEO) database. The regulatory mechanisms of transcription factors in both pan-cancer and GC microenvironments were analysed using the Cancer Genome Atlas (TGCA) database.

Comparative efficacy and safety of pulmonary surfactant delivery strategies in neonatal RDS: a network meta-analysis.

Purpose: To compare five pulmonary surfactant (PS) administration strategies for neonates with respiratory distress syndrome (RDS), including intubation-surfactant-extubation (InSurE), thin catheter administration, laryngeal mask airway (LMA), surfactant nebulization (SN), and usual care, with a particular emphasis on the comparison of the LMA and SN with other strategies.

Methods: We conducted a systematic search of MEDLINE, EMBASE, PUBMED, and Cochrane CENTRAL databases up to November 2023. Two authors independently conducted data extraction, and assessed bias using the Cochrane Risk of Bias Tool.

The role of ALDHs in lipid peroxidation-related diseases.

Lipid peroxidation presents the oxidative degradation of polyunsaturated fatty acids lincited by reactive species. Excessive accumulation of lipid peroxidation byproducts, including 4-hydroxy-2-nonenal (4-HNE) and malondialdehyde (MDA), causes protein dysfunction and various illnesses. Aldehyde dehydrogenases (ALDHs) catalyze the metabolism of both endogenous and exogenous aldehydes.

Investigation of the Mechanism of and Its Associated Autophagy-Related Genes in Gastric Cancer.

Purpose: Semaphorin 5A () and autophagy-related genes (ARGs) are pivotal in the pathogenesis of gastric cancer (GC). However, the potential regulatory role of in autophagy its associated ARGs and the underlying molecular mechanisms remain unresolved.

Patients And Methods: GC-related datasets from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) were analyzed to identify differentially expressed genes (DEGs) between GC and control samples.

Case report: The diagnostic pitfall of Warthin-like mucoepidermoid carcinoma.

Warthin-like mucoepidermoid carcinoma (WL-MEC) is a newly reported variant of mucoepidermoid carcinoma. Its histological feature is easy to confused with metaplastic Warthin Tumor, and its relationship with Warthin tumor in histogenesis is controversial. In this study, we presented two cases of WL-MEC, discussing their clinicopathological and molecular features.

Ameloblastic fibrosarcoma of the maxilla arising in an old woman, a rare case report and literature review.

Background: Ameloblastic fibrosarcoma (AFS) is a rare malignant odontogenic tumor, commonly occurring in young adults and typically affecting the mandibular region. We report an exceptionally rare and highly atypical case of AFS in an elderly female patient originating from the maxillary bone.

Case Presentation: A 66-year-old woman was admitted with a two-week history of a lump in her left upper molar.

Improved desalination performance of flow-electrode capacitive deionisation by a novel drop-shape channel.

As an emerging desalination technology, flow-electrode capacitive deionisation (FCDI) has the advantages of theoretically infinite adsorption capacity and applicability to high-concentration brine. However, during the operation of FCDI, the flow electrode in the S-shape channel is prone to sedimentation and clogging the channel. This undesirable phenomenon brings low efficiency and security issues.

A preliminary attempt at capacitive deionization with PVA/PSS gel coating as an alternative to ion exchange membrane.

PVA/PSS composite gel membrane electrode for membrane capacitive deionization (MCDI) was fabricated and characterised in the present study. The composite electrode with ion exchange surface is prepared by coating glutaraldehyde cross-linked polyvinyl alcohol (PVA) composite hydrogel, with Poly (Sodium 4-Styrenesulfonate) (PSS) added into the network, on the surface of activated carbon (AC) electrode. The feasibility of the gel membrane is analyzed by rheological, swelling rates and ion exchange capacity tests.

Opto-Lipidomics of Tissues.

Lipid metabolism and signaling play pivotal functions in biology and disease development. Despite this, currently available optical techniques are limited in their ability to directly visualize the lipidome in tissues. In this study, opto-lipidomics, a new approach to optical molecular tissue imaging is introduced.

Synchronous multiple primary cancers involving rectal cancer and pelvic classical hodgkin lymphoma: the first case report.

Multiple primary cancers (MPC) are characterized by the presence of synchronous and metachronous occurrence of two or more distinct histological tumor types. In this study, an exceptional clinical case was presented, demonstrating the coexistence of rectal adenocarcinoma and pelvic classical Hodgkin lymphoma (cHL). A 65-year-old male patient with a 2-year history of persistent mucous bloody stools was admitted to our hospital.

[Leptin-mediated ERK Signaling Pathway Promotes the Transformation of Rat Alveolar Type II Epithelial Cells Induced by Yunnan Tin Mine Dust].

Background: Currently, a significant number of miners are involved in mining operations at the Gejiu tin mine in Yunnan. This occupational setting is associated with exposure to dust particles, heavy metals, polycyclic aromatic hydrocarbons, and radioactive radon, thereby significantly elevating the risk of lung cancer. This study aims to investigate the involvement of leptin-mediated extracellular regulated protein kinase (ERK) signaling pathway in the malignant transformation of rat alveolar type II epithelial cells induced by Yunnan tin mine dust.

Case Report: Tumor-to-tumor metastasis with prostate cancer metastatic to lung cancer: the first reported case.

Tumor-to-tumor metastasis (TTM) occurs rarely in tumor progression, but this event has significant clinical implications. Although the impact of TTM on patient prognosis and survival has been increasingly recognized, understanding of TTM biology and treatment is limited. Prostate cancer is among the most common malignancies threatening male health.

Pan-cancer analysis of as a potential immunotherapeutic target.

Increasing evidence supports the connection between the progression of several cancers and BRK1. However, the clinical significance of aberrant BRK1 gene expression in cancer is unknown. This study is conducted to investigate the possibility and effect of BRK1 as a potential immunotherapy target, to deliver a better option for liver cancer immunotherapy.

Induced Pluripotent Stem Cells and Their Applications in Amyotrophic Lateral Sclerosis.

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that results in the loss of motor function in the central nervous system (CNS) and ultimately death. The mechanisms underlying ALS pathogenesis have not yet been fully elucidated, and ALS cannot be treated effectively. Most studies have applied animal or single-gene intervention cell lines as ALS disease models, but they cannot accurately reflect the pathological characteristics of ALS.

Apolipoprotein E facilitates titanium implant osseointegration by regulating osteogenesis-lipogenesis balance.

Apolipoprotein E (ApoE), a protein closely related to various metabolic diseases, is recently considered to play an essential role in bone metabolism. However, the effect and mechanism of ApoE on implant osseointegration have not been clarified. This study aims to investigate the influence of additional ApoE supplementation in regulating the osteogenesis-lipogenesis balance on bone marrow mesenchymal stem cells (BMMSCs) cultured on titanium surface, and the effect of ApoE on the osseointegration of titanium implants.

Classifying epileptic phase-amplitude coupling in SEEG using complex-valued convolutional neural network.

EEG phase-amplitude coupling (PAC), the amplitude of high-frequency oscillations modulated by the phase of low-frequency oscillations (LFOs), is a useful biomarker to localize epileptogenic tissue. It is commonly represented in a comodulogram of coupling strength but without coupled phase information. The phase-amplitude coupling is also found in the normal brain, and it is difficult to discriminate pathological phase-amplitude couplings from normal ones.

Real-Time Detection of Circulating Tumor Cells in Bloodstream Using Plasmonic Fiber Sensors.

Circulating tumor cells (CTCs) are single cancer cells or cancer cell clusters that are present in the circulatory system. Assessing CTC levels in patients can aid in the early detection of cancer metastasis and is essential for the purposes of accurate cancer prognosis. However, current in vitro blood tests are limited by the insufficient blood samples and low concentration levels of CTCs, which presents a major challenge for practical biosensing devices.

Maresin1 Suppresses High-Glucose-Induced Ferroptosis in Osteoblasts via NRF2 Activation in Type 2 Diabetic Osteoporosis.

Maresin1 (MaR1) is an endogenous pro-resolving lipid mediator produced from polyunsaturated fatty acids and is believed to have antioxidant and anti-inflammatory properties. The objective of this study was to estimate MaR1's impact on type 2 diabetic osteoporosis (T2DOP) and its pharmacological mode of action. An in vitro high-glucose model of the osteoblast cell line MC3T3-E1 was constructed and stimulated with MaR1.

A high spatial resolution osteogenic differentiation in human mesenchymal stem cells induced by femtosecond laser.

A variety of physical and chemical methods have been developed in research laboratories for the induction of stem cell differentiation. However, the use of exogenous chemicals and materials may limit their widespread utility in clinics. To develop a clean and precise induction approach with minimal invasion, we reported here that 1-second stimulation by a tightly focused femtosecond laser (fsL) (140 mW/μm , 200 fs) can modulate the signaling systems in human mesenchymal cells, such as intracellular calcium and reactive oxygen species.

Pristimerin exerts antitumor activity against MDA-MB-231 triple-negative breast cancer cells by reversing of epithelial-mesenchymal transition via downregulation of integrin β3.

Background: Pristimerin, a natural flavonoid compound, has potential anti-tumor activities. These activities have been illustrated in various cancer cell lines, including MDA-MB-231 cells. MDA-MB-231 cells are a representative mesenchymal subtype of triple negative breast cancer (MES-TNBC) cell line.

Effect of anion-exchange membrane type for FCDI performance at different concentrations.

Brackish water was an important alternative source of freshwater. Desalination using flow electrode capacitive deionization (FCDI) needs to explore the role of ion exchange membranes (IEM) of FCDI. In this study, brackish water was desalinated using FCDI, and anion exchange membranes with different characteristics were used in the FCDI cell to investigate their influence.

Stem cell differentiation with consistent lineage commitment induced by a flash of ultrafast-laser activation in vitro and in vivo.

Recent technological advancements on stem cell differentiation induction have been making great progress in stem cell research, regenerative medicine, and therapeutic applications. However, the risk of off-target differentiation limits the wide application of stem cell therapy strategies. Here, we report a non-invasive all-optical strategy to induce stem cell differentiation in vitro and in vivo that activates individual target stem cells in situ by delivering a transient 100-ms irradiation of a tightly focused femtosecond laser to a submicron cytoplasmic region of primary adipose-derived stem cells (ADSCs).