Local anaesthesia with conscious sedation in parotid gland tumour resection: a retrospective review.

Objectives: This study explored the suitability of local anaesthesia with conscious sedation for parotid gland tumour surgery.

Methods: Three hundred sixty-four medical records were reviewed to gather data on several key aspects for retrospective analysis. These included age, incision length, operation time, tumour size, NNIS score, ASA score, and pathology.

Deep Learning-based Segmentation of Cervical Posterior Longitudinal Ligament Ossification in CT Images and Assessment of Spinal Cord Compression: A Two-center Study.

Objective: This study aims to develop a fully automated, CT-based deep learning（DL） model to segment ossified lesions of the posterior longitudinal ligament (OPLL) and to measure the thickness of the ossified material and calculate the cervical spinal cord compression factor.

Materials And Methods: A total of 307 patients were enrolled, with 260 patients from Shanghai Changzheng Hospital, And 47 patients from the Traditional Chinese Medicine Hospital of Southwest Medical University. CT images were used to manually segment the OPLL by four experienced radiologists.

Effects of Substrate Temperature on Optical, Structural, and Surface Properties of Metal-Organic Vapor Phase Epitaxy-Grown MgZnO Films.

MgZnO possesses a tunable bandgap and can be prepared at relatively low temperatures, making it suitable for developing optoelectronic devices. MgZnO (~0.1) films were grown on sapphire by metal-organic vapor phase epitaxy under different substrate-growth temperatures of 350-650 °C and studied by multiple characterization technologies like X-ray diffraction (XRD), spectroscopic ellipsometry (SE), Raman scattering, extended X-ray absorption fine structure (EXAFS), and first-principle calculations.

A CT-Based Lung Radiomics Nomogram for Classifying the Severity of Chronic Obstructive Pulmonary Disease.

Background: Chronic obstructive pulmonary disease (COPD) is a major global health concern, and while traditional pulmonary function tests are effective, recent radiomics advancements offer enhanced evaluation by providing detailed insights into the heterogeneous lung changes.

Purpose: To develop and validate a radiomics nomogram based on clinical and whole-lung computed tomography (CT) radiomics features to stratify COPD severity.

Patients And Methods: One thousand ninety-nine patients with COPD (including 308, 132, and 659 in the training, internal and external validation sets, respectively), confirmed by pulmonary function test, were enrolled from two institutions.

Heterogeneous interfaces in confined microdomains of glycyrrhizic acid for polymorphism selection: Mechanisms and applications.

Understanding the mechanisms of heterogeneous nucleation to improve the precision and applicability of polymorphism selection remains challenging. In this study, the formation of confined microdomains with heterogeneous interfaces in the micelle and gel systems were reported based on the supramolecular self-assembly of glycyrrhizic acid. The polymorph with high-purity preparation of isonicotinamide and nicotinamide was achieved due to the high degree of supersaturation and diverse nucleation pathways.

Stress-eliminated liquid-phase fabrication of colloidal films above the critical crack thickness.

The thickness of film materials is a critical factor influencing properties such as energy density, optical performance, and mechanical strength. However, the long-standing challenge of the intrinsic thermodynamic limit on maximum thickness often leads to detrimental cracking, compromising these desirable properties. In this study, we present an approach called the stress-eliminated liquid-phase fabrication (SELF) method.

CT-based whole lung radiomics nomogram to identify middle-aged and elderly COVID-19 patients at high risk of progressing to critical disease.

Background: COVID-19 remains widespread and poses a threat to people's physical and mental health, especially middle-aged and elderly individuals. Early identification of COVID-19 patients at high risk of progressing to critical disease helps improve overall patient outcomes and healthcare efficiency.

Purpose: To develop a radiomics nomogram to predict the risk of newly admitted middle-aged and elderly COVID-19 patients progressing to critical disease.

Programmable and rapid fabrication of complex-shape ceramics.

Shaping of ceramics is crucial. Current techniques cannot easily and rapidly shape ceramics without weakening their properties, especially for piezoceramics. We present an ultrafast ceramic shaping method that leverages thermomechanical fields to deform and sinter ceramic powder compacts into complex-shaped ceramics.

Virtual X-ray critical dimension metrology via Monte Carlo simulation.

X-ray critical dimension (XCD) metrology is a highly promising technique for achieving sub-nanometer precision in critical dimension measurements at advanced nodes of integrated circuit manufacturing. Compared to XCD experiments utilizing synchrotron radiation sources, those employing compact X-ray sources encounter challenges like extended testing time and increased uncertainty. To evaluate the influence of experimental conditions on measurement results, we developed an virtual X-ray critical dimension metrology via a Monte Carlo simulation (MC-VXCD).

Ptychographic Mueller matrix imaging (PMMI): principle and proof-of-concept demonstration.

Quantitative characterization of optical anisotropies is extremely important for wide fields and applications. The Mueller matrix, providing all the polarization-related properties of a medium, is a powerful tool for the comprehensive evaluation of optical anisotropies. Here, we propose a ptychographic Mueller matrix imaging (PMMI) technique, which features the Mueller matrix polarization modulation being introduced into the ptychography.

One-step high-speed thermal-electric aerosol printing of piezoelectric bio-organic films for wirelessly powering bioelectronics.

Piezoelectric biomaterials hold a pivotal role in the progression of bioelectronics and biomedicine, owing to their remarkable electromechanical properties, biocompatibility, and bioresorbability. However, their technological potential is restrained by certain challenges, including precise manipulation of nanobiomolecules, controlling their growth across nano-to-macro hierarchy, and tuning desirable mechanical properties. We report a high-speed thermal-electric driven aerosol (TEA) printing method capable of fabricating piezoelectric biofilms in a singular step.

Lung field-based severity score (LFSS): a feasible tool to identify COVID-19 patients at high risk of progressing to critical disease.

Background: Coronavirus disease 2019 (COVID-19) still poses a threat to people's physical and mental health. We proposed a new semi-quantitative visual classification method for COVID-19, and this study aimed to evaluate the clinical usefulness and feasibility of lung field-based severity score (LFSS).

Methods: This retrospective study included 794 COVID-19 patients from two hospitals in China between December 2022 and January 2023.

Design and synthesis of triazolopyridine derivatives as potent JAK/HDAC dual inhibitors with broad-spectrum antiproliferative activity.

A series of triazolopyridine-based dual JAK/HDAC inhibitors were rationally designed and synthesised by merging different pharmacophores into one molecule. All triazolopyridine derivatives exhibited potent inhibitory activities against both targets and the best compound 4-(((5-(benzo[][1, ]dioxol-5-yl)-[1, 2, 4]triazolo[1, 5-]pyridin-2-yl)amino)methyl)--hydroxybenzamide (19) was dug out. 19 was proved to be a pan-HDAC and JAK1/2 dual inhibitor and displayed high cytotoxicity against two cancer cell lines MDA-MB-231 and RPMI-8226 with IC values in submicromolar range.

Effects of frailty on patients with oral and maxillofacial space infection: a retrospective analysis.

Objectives: To investigate the implications of frailty as a predictive factor for outcomes among patients with oral and maxillofacial space infection.

Methods: A retrospective cohort study was conducted to analyze 348 medical records, gathering data on several key aspects. These included the etiology of infection, the location of inflamed areas, the treatment administered, and the ultimate treatment outcomes.

Tiny pH-Resolved DNA Nanospheres for Cellular Pyroptosis or Apoptosis Regulation.

The design and synthesis of nanomedicines capable of regulating programmed cell death patterns to enhance antitumor efficacy remain significant challenges in cancer therapy. In this study, we developed intelligent DNA nanospheres (NS) capable of distinguishing tiny pH changes between different endosomal compartments to regulate pyroptosis or apoptosis. These NS are self-assembled from two multifunctional DNA modules, enabling tumor targeting, acid-responsive disassembly, and photodynamic therapy (PDT) activation.