Publications by authors named "Shiyu Yang"

Although depression significantly impacts fitness, some hypotheses suggest that it may offer a survival benefit. However, there has been limited systematic investigation into the selection pressures acting on genes associated with depression at the genomic level. Here, we conducted comparative genomic analyses and computational molecular evolutionary analyses on 320 depression-associated genes at two levels, i.

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Ulcerative colitis (UC), a chronic inflammatory bowel disease with increasing global incidence and limited therapeutic options, underscores the urgent need for novel multi-target agents. Swertiamarin (STM), a secoiridoid glycoside derived from traditional medicine, exhibits anti-inflammatory properties, but its pharmacological mechanisms in UC remain unclear. In this study, we integrated network pharmacology and experimental validation to systematically decipher STM's therapeutic effects.

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Hydrophobic modification alters the properties of Pluronic F127 to form micelles more efficiently and enhances its drug-loading capacity. However, selecting the appropriate hydrophobic group for modification is laborious. In this paper, we propose an efficient approach for predicting key parameters to select hydrophobic groups for F127 modification prior to synthesis, in order to improve the formability and stability of the micelles.

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Organic hole-transporting materials (HTMs) with high hole mobility and a defect passivating ability are critical for improving the performance and stability of perovskite optoelectronics, including perovskite quantum dot light-emitting diodes (Pe-QLEDs) and perovskite solar cells. In this study, we designed two small-molecule HTMs, termed and , incorporating the methylthio group (SMe) as defect-passivating sites to enhance the interaction between HTMs and the perovskite layer for Pe-QLED applications. Our study highlights that , featuring SMe groups at the para-position of the carbazole unit, demonstrates a strong interaction and superior passivation effects with perovskite quantum dots.

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Background: Cilia are specialized microtubule-based organelles that extend from the cell surface and are classified into non-motile and motile types. The assembly and function of cilia are regulated by a complex molecular network that enables motile cilia to generate fluid flow across epithelial surfaces through coordinated beating. These motile cilia are found in the respiratory, nervous, and reproductive systems.

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Mass shootings are devastating events. Communities can cope with the ensuing trauma in a number of ways, including changing their behavioral patterns. Using point-of-sale data from 35,000 individual retailers, including more than half of all American grocery and drugstore purchases, and all American mass shootings from 2006 to 2019, we find, in a set of two-way fixed-effects counterfactual analyses, that a mass shooting in a given community (the area covered by the ZIP-3 code) predicts a significant increase in the sales of alcohol that lasts at least 2 years past the shooting.

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Asthma is a chronic inflammatory respiratory disease that affects millions globally and poses a serious public health challenge. Current therapeutic strategies, including corticosteroids, are constrained by variable patient responses and adverse effects. In this study, a polyphenolic extract derived from the Tibetan medicinal plant Trimen (SRT) was employed and shown to improve experimentally (ovalbumin + cigarette smoke, OVA + CS) induced asthma in rats.

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(), one of the most prevalent pathogenic bacteria worldwide, is the leading cause of gastritis, gastric intestinal metaplasia, and gastric cancer. Antibiotics, the conventional treatment for eliminating , often lead to severe bacterial resistance, gut dysbiosis, and hepatic insufficiency and fail to address the inflammatory response or gastric mucosal damage caused by infection. In this study, based on 10-week animal experiments, two models of NCUH062003 for the prophylaxis and therapy of infection in C57BL/6 mice were established; a comprehensive comparative analysis was performed to investigate the anti- effect of probiotics, the reduction in inflammation, and repair of gastric mucosal damage.

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Background: microRNAs (miRNAs) could mediate the glucose and lipid metabolism progress in metabolic syndrome (MetS).

Objectives: To analyze the value of miRNA (miR)-21-5p for MetS diagnosis in children with obesity. Function of miR-21-5p has been explored by the prediction of target genes and functional and pathway enrichment analysis.

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Meiosis in males is a critical process that ensures complete spermatogenesis and genetic diversity. However, the key regulators involved in this process and the underlying molecular mechanisms remain unclear. Here, we report an essential role of the mA methyltransferase METTL16 in meiotic sex chromosome inactivation (MSCI), double-strand break (DSB) formation, homologous recombination and SYCP1 deposition during male meiosis.

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Background: Takayasu arteritis (TA) is associated with an increased risk of developing complicated comorbidities, which can bring both psychological and physical burdens to the patients.

Objective: TA is found to carry a high risk of developing depression. This research aimed to investigate the risk factors and prognosis of depression in TA patients.

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Article Synopsis
  • Early-life exposure to tobacco smoke is linked to a higher risk of chronic kidney disease (CKD) in adulthood, with significant increases in CKD incidence for individuals exposed in utero and those who started smoking at younger ages.
  • The study involved over 350,000 participants from the UK Biobank and used statistical methods to analyze the relationship between tobacco exposure, the age at which participants started smoking, and their physical activity levels.
  • Results indicated that physical activity can influence the risk of CKD, highlighting the importance of early tobacco control efforts and promoting physical activity to help reduce CKD risk later in life.
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Background: Disturbed metabolism and transport of citrate play significant roles in various pathologies. However, vascular citrate regulation and its potential role in aortic aneurysm (AA) development remain poorly understood.

Methods: Untargeted metabolomics by mass spectrometry was applied to identify upregulated metabolites of the tricarboxylic acid cycle in AA tissues of mice.

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  • Coronary artery involvement (CAI) is a notable yet not uncommon outcome of Takayasu arteritis (TAK), and this study aimed to explore the role of Granzyme B (GzmB) in patients with TAK and CAI.
  • The research included 105 TAK patients and 58 healthy controls, finding significant differences in various health metrics and an increased presence of certain immune cell types (CD3+CD8+ and CD3+CD4+) among TAK patients with CAI.
  • The study concluded that a higher ratio of CD3+CD8+GzmB+ cells in lymphocytes could serve as an independent risk factor for CAI and major adverse cardiovascular events (MACE), suggesting that targeting
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  • Finding water on the Moon is essential for future lunar missions, but current resources of hydroxyl (OH) and natural water (HO) are limited.
  • Researchers propose generating water through a chemical reaction involving lunar regolith (composed of FeO) and hydrogen retained from the solar wind, demonstrating that significant amounts of HO can be produced by heating lunar soil above 1,200 K.
  • The study highlights that the mineral FeTiO ilmenite is particularly rich in hydrogen, and the work also reveals how heating causes the simultaneous formation of iron crystals and water bubbles, providing insight into water resource potential for lunar research stations.
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Background: Recent studies have found that histone-modified genes play an increasingly important role in tumor progression. Lysine(K) specific demethylase 4A (KDM4A) is a histone lysine-specific demethylase highly expressed in a variety of malignant tumors, data showed that KDM4A was negatively correlated with the Bone Morphogenetic Protein 9 (BMP9) in breast cancer. And previous experiments have demonstrated that exogenous BMP9 significantly inhibits breast cancer development.

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Inhibitor of β-catenin and T-cell factor (ICAT) is a classical inhibitor of the Wnt signaling pathway. Nonetheless, our previous work found that ICAT is overexpressed in cervical cancer (CC), resulting in the augmentation of migration and invasion capabilities of CC cells. It remains unclear what molecular mechanism underlies this phenomenon.

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Background: Although intracoronary electrocardiography (IC-ECG) offers direct electrophysiological insights into myocardial ischemia caused by insufficient coronary blood supply, compared to common diagnostic methods like electrocardiography (ECG), it lacks widespread adoption and robust clinical research.

Objective: To analyze the value and accuracy of intracoronary electrocardiogram in myocardial ischemia diagnosis in coronary heart disease patients.

Methods: Three hundred patients treated at our hospital were included in the study.

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CuZnSnS (CZTS) is strong candidate for hole transport in perovskite light emitting diodes (PeLEDs) due to their cost-effectiveness, deep highest occupied molecular orbital (HOMO), and high hole mobility. However, its inherent polymetallic ions usually deteriorate the quality of the perovskite emission layer (EML) affecting device performance. In this study, a bidirectional anchoring strategy is proposed by adding 15-crown-5 ether (15C5) into CZTS hole transport layer (HTL) to suppress the reaction between HTL and EML.

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Biomechanical contributions of the extracellular matrix underpin cell growth and proliferation, differentiation, signal transduction, and other fate decisions. As such, biomaterials whose mechanics can be spatiotemporally altered- particularly in a reversible manner- are extremely valuable for studying these mechanobiological phenomena. Herein, a poly(ethylene glycol) (PEG)-based hydrogel model consisting of two interpenetrating step-growth networks is introduced that are independently formed via largely orthogonal bioorthogonal chemistries and sequentially degraded with distinct recombinant sortases, affording reversibly tunable stiffness ranges that span healthy and diseased soft tissues (e.

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Article Synopsis
  • Sperm DNA fragmentation testing can predict male infertility and may influence in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) outcomes, but its impact on live birth rates is uncertain.
  • A study involving 5050 couples from 2016 to 2022 categorized participants based on sperm DNA fragmentation levels and assessed cumulative live birth rates after one year of treatment.
  • Results indicated that while overall live birth rates were similar across groups, significant decreases were observed in ICSI patients with high sperm DNA fragmentation (>10%), particularly in those with fragmentation rates exceeding 30%.
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  • - Prolonged exposure to crystalline silica (CS) can lead to silicosis, which causes serious lung inflammation and fibrosis; this study investigates how changes in glycolysis (a metabolic process) contribute to these effects.
  • - Using mouse models, researchers found that CS exposure leads to lung inflammation, enhanced glycolysis, and a form of cell death called pyroptosis, which can be reduced by the glycolysis inhibitor 2-DG.
  • - The study suggests that the metabolite lactate from glycolysis boosts pyroptosis through NLRP3 inflammasome activation, and inhibiting glycolysis may help manage the inflammatory responses associated with CS exposure.
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In mammals, the transition from mitosis to meiosis facilitates the successful production of gametes. However, the regulatory mechanisms that control meiotic initiation remain unclear, particularly in the context of complex histone modifications. Herein, we show that KDM2A, acting as a lysine demethylase targeting H3K36me3 in male germ cells, plays an essential role in modulating meiotic entry and progression.

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The mechanisms underlying relationships between ambient air pollution and chronic obstructive pulmonary disease (COPD) risk remained largely uncertain. In this study, we aim to evaluate whether metabolic signature comprising multiple circulating metabolites can characterize metabolic response to the multiple air pollution; and to assess whether the identified metabolic signature contribute to COPD risk. A total of 227,962 participants with complete data were included from the UK biobank study.

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