Redox imbalance drives magnetic property and function changes in mice.

The magnetic properties of substances directly determine their response to an externally applied magnetic field, which are closely associated with magnetoreception, magnetic resonance imaging (MRI), and magnetic bioeffects. However, people's understanding of the magnetic properties of living organisms remains limited. In this study, we utilized NRF2 (nuclear factor erythroid 2-related factor 2) deficient mice to investigate the contribution of redox (oxidation-reduction) homeostasis, in which the key process is the transfer of electron, a direct target of magnetic field and origin of paramagnetism.

Design and screening of novel molecular compounds targeting lactate dehydrogenase of Babesia microti.

Background: Human babesiosis is caused by several species within the Babesia genus, primarily Babesia microti, Babesia duncani, and Babesia divergens, all of which infect human red blood cells (RBCs). Clinically, the disease manifests with symptoms such as fever, anemia, jaundice, and hemoglobinuria, with B. microti being the most prevalent of these species.

A systematic review of the efficacy of repetitive transcranial magnetic stimulation in treating dysarthria in patients with Parkinson's disease.

Objective: To analyze the literature on the efficacy of repetitive transcranial magnetic stimulation (rTMS) in treating dysarthria in patients with Parkinson's disease (PD) and provide a reference for targeted clinical treatment of dysarthria in PD patients.

Methods: A systematic search was conducted in English and Chinese databases, including Embase, Cochrane, Medline, PubMed, CNKI, Wanfang, Chinese Biomedical Literature Database, and VIP Database, for relevant literature on rTMS treatment for dysarthria in PD patients. The search timeframe was from the inception of each database to October 2023.

PD-associated peritonitis: Something's fishy.

Peritoneal dialysis (PD)-associated peritonitis commonly arises from touch contamination events, however, it is important to be mindful of alternative etiologies and to take a detailed history and perform a root cause analysis for each episode. In fact, the PD effluent can be a window into intra-abdominal pathologies which may require surgical management. We present an unusual case of secondary enteric peritonitis due to foreign body bowel perforation from ingestion of a fish bone.

The antioxidant role of aromatic plant extracts in managing neurodegenerative diseases: A comprehensive review.

Neurodegenerative diseases (NDDs) are a class of cognitive and motor disorders including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), Amyotrophic Lateral Sclerosis (ALS), and others. They are caused by lesions in cells and tissues of the central nervous system, resulting in corresponding dysfunctions and consequent decline in cognitive and motor functions. Neural tissues are extremely vulnerable to oxidative stress, which plays critical biological roles in NDDs.

Primary Care-Based Digital Health-Enabled Stroke Management Intervention: Long-Term Follow-Up of a Cluster Randomized Clinical Trial.

Importance: Despite evidence of the short-term benefits of multicomponent primary care-based interventions, their long-term effects are unproven.

Objective: To evaluate the long-term outcomes of a system-integrated technology-enabled model of care (SINEMA intervention) for stroke management for systolic blood pressure (BP) and other outcomes among patients with stroke in China.

Design, Setting, And Participants: This long-term follow-up included community-dwelling clinically stable surviving participants with stroke in an open-label cluster randomized clinical trial.

Intracranial aneurysm instability prediction model based on 4D-Flow MRI and HR-MRI.

This study aims to develop a reliable predictive model for assessing intracranial aneurysm (IA) instability by utilizing four-dimensional flow magnetic resonance imaging (4D-Flow MRI) and high-resolution MRI (HR-MRI). Initially, we curated a prospective dataset, dubbed the primary cohort, by aggregating patient data that was consecutively enrolled across two centers from November 2018 to November 2021. Unstable aneurysms were defined as those with symptoms, morphological change or ruptured during follow-up periods.

Flexible Silk Fibroin-Based Triboelectric Nanogenerators with Thermal Management Capabilities for Temperature Regulation and Self-Powered Monitoring.

Flexible triboelectric nanogenerators (TENGs) are highly advantageous for human-centered monitoring due to their self-sustaining energy and high output performance. However, temperature fluctuations that limit thermal comfort have hindered their practical advancement. In this study, flexible titanium dioxide-silk fibroin@phase change microcapsule nanofiber films (TiO-SF@PCM NFs) were successfully developed using an efficient electro-blown spinning (EBS) technique, with exceptional triboelectric output and superior temperature regulation capabilities.

Protective mechanism of Prim-O-glucosylcimifugin in the treatment of osteoarthritis: Based on lncRNA XIST regulation of Nav1.7.

LncRNA XIST and Nav1.7 have been identified to be significantly associated with the onset of osteoarthritis. Prim-O-glucosylcimifugin (POG) has antiinflammatory and analgesic effects in treating osteoarthritis (OA).

Understanding Organizational Resilience of Care Homes for Older People During COVID-19 in China: A Qualitative Study with Post-Pandemic Policy Implications.

The COVID-19 pandemic presented unprecedented challenges for residential care homes for older people. However, the obstacles they faced and their resilience strategies have received insufficient research attention. This study, focusing on 13 residential care homes in Southeast China, addressed this research gap.

Chromosome-level genome assembly of Huai pig (Sus scrofa).

Although advances in long-read sequencing technology and genome assembly techniques have facilitated the study of genomes, little is known about the genomes of unique Chinese indigenous breeds, including the Huai pig. Huai pig is an ancient domestic pig breed and is well-documented for its redder meat color and high forage tolerance compared to European domestic pigs. In the present study, we sequenced and assembled the Huai pig genome using PacBio, Hi-C, and Illumina sequencing technologies.

Promoting Late-Life Volunteering With Timebanking: A Quasi-Experimental Mixed-Methods Study in Hong Kong.

Background And Objectives: This study explores the impact of timebanking, where individuals earn time credits, nonmonetary currency, on promoting volunteerism among older adults.

Research Design And Methods: This study employed a quasi-experimental design with 116 timebank group (TBG) participants and 114 comparison group (CG) participants from 2021 to 2022. TBG received time credits to exchange for rewards, while CG received no time credits (i.

Aging and Caring: Exploring Older Adults' Motivation for Informal Caregiving to Other Aging Individuals in Nigeria.

Background And Objectives: Because of the global population aging, more informal carers become older adults. In Nigeria, the African country with the largest population of adults aged 60 years and older, self-construal rooted in the African collectivist philosophy generally shapes informal caregiving for older adults. However, there is a general paucity of studies on older adults' informal caregiving roles, particularly about their motivations for caregiving.

Objective and perceived service accessibility and mental health in older adults.

Objectives: Service accessibility plays a pivotal role in older adults' mental health. However, accessibility measures used in previous studies are either objective or perceived. This study aimed to integrate both objective and perceived measures of service accessibility to explore the relationship between environmental cognition on service accessibility and mental health in older adults and the pathways.

Stage-by-Stage Wavelet Optimization Refinement Diffusion Model for Sparse-View CT Reconstruction.

Diffusion model has emerged as a potential tool to tackle the challenge of sparse-view CT reconstruction, displaying superior performance compared to conventional methods. Nevertheless, these prevailing diffusion models predominantly focus on the sinogram or image domains, which can lead to instability during model training, potentially culminating in convergence towards local minimal solutions. The wavelet transform serves to disentangle image contents and features into distinct frequency-component bands at varying scales, adeptly capturing diverse directional structures.

Assembly of novel sequences for Chinese domestic pigs reveals new genes and regulatory variants providing new insights into their diversity.

There is an increasing understanding that a reference genome representing an individual cannot capture all the gene repertoire of a species. Here, we conduct a population-scale missing sequences detection of Chinese domestic pigs using whole-genome sequencing data from 534 individuals. We identify 132.

Facile Synthesis of Basic Copper Carbonate Nanosheets for Photoacoustic Imaging-Guided Tumor Apoptosis and Ferroptosis and the Extension Exploration of the Synthesis Method.

Elimination of tumor cells using carbonate nanomaterials with tumor microenvironment-responsive capacity has been explored as an effective strategy. However, their therapeutic outcomes are always compromised by the relatively low intratumoral accumulation and limited synthesis method. Herein, a novel kind of basic copper carbonate nanosheets was designed and prepared using a green synthesis method for photoacoustic imaging-guided tumor apoptosis and ferroptosis therapy.

Transcriptional variation in Babesia gibsoni (Wuhan isolate) between in vivo and in vitro cultures in blood stage.

Background: Babesia gibsoni, the causative agent of canine babesiosis, belongs to the phylum Apicomplexa. The development of in vitro culture technology has driven research progress in various kinds of omics studies, including transcriptomic analysis of Plasmodium spp. between in vitro and in vivo environments, which has prompted the observation of diagnostic antigens and vaccine development.

Functional Ability and Its Associated Factors Among Chinese People Aged 50 Years and Above from the Perspective of Healthy Aging: A 7-Year Longitudinal Study.

Although a new conceptualization of functional ability was proposed in the Decade of Healthy Aging, few studies attempted to understand functional ability among older adults from a holistic review. Based on the China Health and Retirement Longitudinal Study from 2011 to 2018, the study investigated the current situation of five domains of functional ability (ability to self-care, being mobile, building/maintaining relationships, contributing to society, learning, and growing), the overall functional ability score and their associated factors among older people. Compared to other functional ability domains, the ability to contribute to society and learn/grow has been largely underdeveloped.

CRTC2 promotes paclitaxel resistance by inducing autophagy in ovarian cancer in part via the PI3K-AKT signaling axis.

Ovarian cancer is the most malignant gynecological disease, which seriously threatens female physical and mental health. Paclitaxel is a first-line chemotherapy drug in the clinical treatment of ovarian cancer, but drug resistance has become an important factor affecting the survival of ovarian cancer patients. However, the main mechanism of chemotherapy resistance in ovarian cancer remains unclear.

Universities as Intermediary Organizations: Catalyzing the Construction of an Age-Friendly City in Hong Kong.

Background And Objectives: The construction of an Age-Friendly City (AFC) requires active contribution from relevant interest groups including older adults, nonprofit organizations, and policy-makers. However, given that relevant interest groups may have limited resources, knowledge, and skills, as well as unique contextual factors, they often require help from intermediary organizations-actors that aim to build interest groups' capabilities. Our objectives were to examine the functions of universities, as an example of intermediary organizations, in facilitating the construction of an AFC, and identify critical factors that enable intermediary organizations to perform their functions.

First-Principles Calculations on Narrow-Band Gap d Metal Oxides for Photocatalytic H Production: Role of Unusual In Cations in Band Engineering.

The d metal oxides with low effective mass and high mobility of photoexcited electrons have received much attention in photocatalytic water splitting. However, there are still challenges in practical application due to insufficient visible light absorption. Here, an unusual phenomenon of the In cation in PtIn(GeO)O and PtIn(Ga/InO) with a narrow band gap is systematically investigated using density functional theory calculations.