Enhanced Cycling Performance of High-Voltage Solid-State Lithium Batteries via In Situ Cathode-Electrolyte Interface Construction.

The [solvent-Li] complex in poly(vinylidene fluoride) (PVDF)-based polymer electrolytes enables fast ion conduction but also makes it difficult to be compatible with high-voltage cathodes. Here, we demonstrate that the residual amount of solvent significantly affects the ion transport properties and interfacial stability of the electrolyte. In LiNiCoMnO/Li batteries, a nonuniform and unstable double-layer CEI is formed due to the decomposition of desolvated NMP molecules and lithium salts, resulting in aggravated polarization and rapid capacity decay.

An integrated "Engage & Evasion" approach for mononuclear phagocyte system escape and efficient extracellular vesicle therapy.

Ischemic diseases are major contributors to global morbidity and mortality, posing a substantial threat to human health. Extracellular vesicles (EVs) play an essential role in enhancing neovascularization in ischemic tissues, thereby facilitating tissue repair and regeneration. However, the utilization of EVs is hindered by their rapid uptake and clearance by the mononuclear phagocyte system (MPS), which markedly impedes their therapeutic efficacy and organ-specific accumulation.

Linearly Scaling Molecular Dynamic Modeling To Simulate Picosecond Laser Ablation of a Silicon Carbide Crystal.

A molecular dynamics model for picosecond laser ablation of nanoscale silicon carbide crystals was established by linearly scaling the laser focal diameter, and the correlation between the molecular dynamic simulation of the nanoscale and the experimental reproduction of the microscale was achieved. The calculation accuracy of the molecular dynamic model was verified by ablating the surface of silicon carbide wafers with a laser pulse width of 37 ps. On this basis, this paper further investigated the influence of the laser pulse width and fluence on the surface ablation damage and modification width, threshold, and lattice temperature.

Comparing Participation and Interim Effectiveness of Endoscopy and Biomarker-Based Screening for Gastric Cancer: A Cluster Randomized Controlled Trial.

To improve compliance with endoscopic screening for gastric cancer (GC), we assessed five biomarkers-pepsinogen I (PG I), pepsinogen II (PG II), PG I/II ratio, helicobacter pylori antibody (HP-Ab), and gastrin 17 (G17) - for secondary GC screening by comparing participation and effectiveness of traditional endoscopy and biomarker-based screening in a randomized trial with baseline results. Seventy-four communities were randomly assigned to traditional endoscopy arm (TEA) or biomarker-based endoscopy arm (BEA). TEA uses a questionnaire for risk assessment, and BEA combines a questionnaire with biomarker detection.

Oxalate modification enabled advanced phosphate removal of nZVI: In Situ formed surface ternary complex and altered multi-stage adsorption process.

Nano zero-valent iron (nZVI) is a promising phosphate adsorbent for advanced phosphate removal. However, the rapid passivation of nZVI and the low activity of adsorption sites seriously limit its phosphate removal performance, accounting for its inapplicability to meet the emission criteria of 0.1 mg P/L phosphate.

The causal effect of gut microbiota on hepatic encephalopathy: a mendelian randomization analysis.

Background: There is growing evidence for a relationship between gut microbiota and hepatic encephalopathy (HE). However, the causal nature of the relationship between gut microbiota and HE has not been thoroughly investigated.

Method: This study utilized the large-scale genome-wide association studies (GWAS) summary statistics to evaluate the causal association between gut microbiota and HE risk.

Research on Active Safety Situation of Road Passenger Transportation Enterprises: Evaluation, Prediction, and Analysis.

The road passenger transportation enterprise is a complex system, requiring a clear understanding of their active safety situation (ASS), trends, and influencing factors. This facilitates transportation authorities to promptly receive signals and take effective measures. Through exploratory factor analysis and confirmatory factor analysis, we delved into potential factors for evaluating ASS and extracted an ASS index.

Design of a Negative Temperature Coefficient Temperature Measurement System Based on a Resistance Ratio Model.

In this paper, a temperature measurement system with NTC (Negative Temperature Coefficient) thermistors was designed. An MCU (Micro Control Unit) primarily operates by converting the voltage value collected by an ADC (Analog-to-Digital Converter) into the resistance value. The temperature value is then calculated, and a DAC (Digital-to-Analog Converter) outputs a current of 4 to 20 mA that is linearly related to the temperature value.

DDX58 deficiency leads to triple negative breast cancer chemotherapy resistance by inhibiting Type I IFN-mediated signalling apoptosis.

Introduction: Triple-negative breast cancer (TNBC) is characterized by its aggressive nature and absence of specific therapeutic targets, necessitating the reliance on chemotherapy as the primary treatment modality. However, the drug resistance poses a significant challenge in the management of TNBC. In this study, we investigated the role of (DExD/H-box helicase 58), also known as RIG-I, in TNBC chemoresistance.

Biomechanical analysis of the maxillary sinus floor membrane during internal sinus floor elevation with implants at different angles of the maxillary sinus angles.

Objective: This study analyzed and compared the biomechanical properties of maxillary sinus floor mucosa with implants at three different maxillary sinus angles during a modified internal sinus floor elevation procedure.

Methods: 3D reconstruction of the implant, maxillary sinus bone, and membrane were performed. The maxillary sinus model was set at three different angles.

Mechanism and effectiveness of enzymatically induced phosphate precipitation (EIPP) in stabilizing coexisting lead, zinc, and cadmium in tailings.

Lead-zinc (Pb-Zn) tailings ponds carry the risk of multiple heavy metals (HMs) contamination and pile destabilization. This poses requirements for in-situ applicable, low-distribution, and effective stabilization/solidification (S/S) methods. For this, the novel enzymatically induced phosphate precipitation (EIPP) method was implemented in this study.

DNAJC12 causes breast cancer chemotherapy resistance by repressing doxorubicin-induced ferroptosis and apoptosis via activation of AKT.

Background: Chemotherapy is a primary treatment for breast cancer (BC), yet many patients develop resistance over time. This study aims to identify critical factors contributing to chemoresistance and their underlying molecular mechanisms, with a focus on reversing this resistance.

Methods: We utilized samples from the Gene Expression Omnibus (GEO) and West China Hospital to identify and validate genes associated with chemoresistance.

Arginine-methylated c-Myc affects mitochondrial mitophagy in mouse acute kidney injury via Slc25a24.

The transcription factor methylated c-Myc heterodimerizes with MAX to modulate gene expression, and plays an important role in energy metabolism in kidney injury but the exact mechanism remains unclear. Mitochondrial solute transporter Slc25a24 imports ATP into mitochondria and is central to energy metabolism. Gene Expression Omnibus data analysis reveals Slc25a24 and c-Myc are consistently upregulated in all the acute kidney injury (AKI) cells.

Triangle Cl-Ag -Cl Sites for Superior Photocatalytic Molecular Oxygen Activation and NO Oxidation of BiOCl.

BiOCl photocatalysis shows great promise for molecular oxygen activation and NO oxidation, but its selective transformation of NO to immobilized nitrate without toxic NO emission is still a great challenge, because of uncontrollable reaction intermediates and pathways. In this study, we demonstrate that the introduction of triangle Cl-Ag -Cl sites on a Cl-terminated, (001) facet-exposed BiOCl can selectively promote one-electron activation of reactant molecular oxygen to intermediate superoxide radicals (⋅O ), and also shift the adsorption configuration of product NO from the weak monodentate binding mode to a strong bidentate mode to avoid unfavorable photolysis. By simultaneously tuning intermediates and products, the Cl-Ag -Cl-landen BiOCl achieved >90 % NO conversion to favorable NO of high selectivity (>97 %) in 10 min under visible light, with the undesired NO concentration below 20 ppb.

Construction of an OCP-ATR-FTIR Spectroscopy Device to Monitor the Interfacial Reaction of Contaminants: Competitive Adsorption of Cr(VI) and Oxalate on Hematite.

The comprehensive understanding of contaminant interfacial behavior strongly depends on the characterization technique, which is still a great challenge. In this study, we constructed a device integrated with open-circuit potentialand attenuated total reflectance Fourier transform infrared (OCP-ATR-FTIR) spectroscopy to simultaneously monitor the electrochemical and infrared spectral information on the interfacial reaction for the process analysis, taking the competitive adsorption of hexavalent chromium (Cr(VI)) and oxalate on hematite nanocubes (HNC) as an example. The synchronous OCP and infrared results revealed that Cr(VI) interacted with HNC via bidentate binuclear inner-sphere coordination, accompanied by electron transfer from HNC to Cr(VI), while oxalate was adsorbed on HNC through bidentate mononuclear side-on inner-sphere coordination with electron transfer from HNC to oxalate, and also outer-sphere coordination with negative charge accumulation.

Preparation of LiV(PO) as cathode material for aqueous zinc ion batteries by a hydrothermal assisted sol-gel method and its properties.

To alleviate the depletion of lithium resources and improve battery capacity and rate capacity, the development of aqueous zinc-ion batteries (AZIBs) is crucial. The open channels monoclinic structure LiV(PO) is conducive to the transfer and diffusion of guest ions, making it a promising cathode material for AZIBs. Therefore, in this study, nanoneedles and particles LiV(PO) cathode materials for AZIBs were prepared by a hydrothermal assisted sol-gel method, and the effect of synthesized pH values was studied.

Ionic Conductivity and Cycling Performance in PEO Polymer Electrolyte Enhanced by Non-Milled In Situ Nano-LLZO Powders.

High Li conductivity, good interfacial compatibility, and nano-scale particle size have always been essential conditions for selecting inorganic fillers in high-performance composite solid electrolytes. In this study, non-milled in situ LLZO fillers with nanosize was synthesized via the sol-gel method by rapid heating sintering, which resulted in more surface defects and fewer impurities in LLZO. Compared with milled LLZO fillers, these non-milled LLZO fillers with more surface defects and fewer impurities can effectively reduce the crystallinity of PEO and agglomeration in PEO, which can form composite electrolytes with high Li conductivity.

Dual-Coordination-Induced Poly(vinylidene fluoride)/LiGaLaZrO/Succinonitrile Composite Solid Electrolytes Toward Enhanced Rate Performance in All-Solid-State Lithium Batteries.

Pursuing high energy and power density in all-solid-state lithium batteries (ASSLBs) has been the focus of attention. However, due to their inferior ion transport, their rate performance is limited compared to traditional lithium-ion batteries. Herein, a dual-coordination mechanism is first proposed to construct a high-performance poly(vinylidene fluoride)/LiGaLaZrO/succinonitrile (PVDF/LLZO/SN) composite solid electrolyte.

Predicting the prognosis of HER2-positive breast cancer patients by fusing pathological whole slide images and clinical features using multiple instance learning.

In 2022, breast cancer will become an important factor affecting women's public health and HER2 positivity for approximately 15-20$ \% $ invasive breast cancer cases. Follow-up data for HER2-positive patients are rare, and research on prognosis and auxiliary diagnosis is still limited. In light of the findings obtained from the analysis of clinical features, we have developed a novel multiple instance learning (MIL) fusion model that integrates hematoxylin-eosin (HE) pathological images and clinical features to accurately predict the prognostic risk of patients.

Risk assessment of combined exposure to lead, cadmium, and total mercury among the elderly in Shanghai, China.

Lead (Pb), cadmium (Cd) and total mercury (THg) are toxic heavy metals (THMs) that are widely present in the environment and can cause substantial health problems. However, previous risk assessment studies have rarely focused on the elderly population and have usually targeted a single heavy metal, which might underestimate the long-term accumulative and synergistic effects of THMs in humans. Based on the food frequency questionnaire and inductively coupled plasma mass spectrometry, this study assessed external and internal exposures to Pb, Cd and THg in 1747 elderly people in Shanghai.

Electrochemical generation of hydrogen peroxide from a zinc gallium oxide anode with dual active sites.

Electrochemical water oxidation enables the conversion of HO to HO. It holds distinct advantages to the O reduction reaction, which is restricted by the inefficient mass transfer and limited solubility of O in aqueous media. Nonetheless, most reported anodes suffer from high overpotentials (usually >1000 mV) and low selectivity.

Projection of Premature Cancer Mortality in Hunan, China, Through 2030: Modeling Study.

Background: The United Nations Sustainable Development Goals for 2030 include reducing premature mortality from noncommunicable diseases by one-third. Although previous modeling studies have predicted premature mortality from noncommunicable diseases, the predictions for cancer and its subcategories are less well understood in China.

Objective: The aim of this study was to project premature cancer mortality of 10 leading cancers in Hunan Province, China, based on various scenarios of risk factor control so as to establish the priority for future interventions.

Raman spectroscopic and microscopic monitoring of on-site and in-situ remediation dynamics in petroleum contaminated soil and groundwater.

The mechanistic study of soil and groundwater remediation in petroleum contaminated lands significantly demands rapid qualitative and quantitative identification of petroleum substances. However, most traditional detection methods cannot provide the on-site or in-situ information of petroleum compositions and contents simultaneously even with multi-spot sampling and complex sample preparation. In this work, we developed a strategy for the on-site detection of petroleum compositions and in-situ monitoring of petroleum contents in soil and groundwater using dual-excitation Raman spectroscopy and microscopy.