Structure-Activity Relationship of Hemicyanine Molecules: Mitochondrion-Targeting Hemicyanine Fluorescent Molecular Probes for HSO Recognition and Near-Infrared Image-Guided Photothermal/Photodynamic Synergetic Therapy.

Hemicyanine molecules have unparalleled potential in the fields of fluorescence sensing, bioimaging, and disease therapeutics due to their excellent optical properties, cell penetration, potential mitochondrial targeting, and photosensitivity. Herein, three dual-cation hemicyanine molecular probes named , , and were developed. All of them could detect HSO, and could recognize HSO under 365 nm ultraviolet light or sunlight.

Exposure to polystyrene nanoplastics induces hepatotoxicity involving NRF2-NLRP3 signaling pathway in mice.

Nanoplastic contamination has been of intense concern by virtue of the potential threat to human and ecosystem health. Animal experiments have indicated that exposure to nanoplastics (NPs) can deposit in the liver and contribute to hepatic injury. To explore the mechanisms of hepatotoxicity induced by polystyrene-NPs (PS-NPs), mice and AML-12 hepatocytes were exposed to different dosages of 20 nm PS-NPs in this study.

Control of Tooth Form Deformation in Heat Treatment of Spiral Bevel Gears Based on Reverse Adjustment of Cutting Parameters.

The tooth surface structure of spiral bevel gear is complex and requires high machining accuracy. In order to reduce the tooth form deformation of heat treatment, this paper proposes a reverse adjustment correction model of tooth cutting for heat treatment tooth form deformation of spiral bevel gear. Based on the Levenberg-Marquardat method, a stable and accurate numerical solution for the reverse adjustment amount of the cutting parameters is solved.

Toxic effects of per- and polyfluoroalkyl substances on sperm: Epidemiological and experimental evidence.

As emerging organic contaminants, per- and polyfluoroalkyl substances (PFASs) have aroused worldwide concern due to their environmental persistence, ubiquitous presence, bioaccumulation, and potential toxicity. It has been demonstrated that PFASs can accumulate in human body and cause multiple adverse health outcomes. Notably, PFASs have been detected in the semen of human, posing a potential hazard to male fecundity.

Association between clinical characteristics and pain relief in patients with axial spondyloarthritis treated with non-steroidal anti-inflammatory drugs.

Objectives: The aim of this study was to evaluate pain relief in axial spondyloarthritis (axSpA) patients treated with non-steroidal anti-inflammatory drugs (NSAIDs) and to investigate the relation of the demographic, clinical, and psychological characteristics with pain relief.

Patients And Methods: Between February 2017 and December 2019, a total of 94 patients (61 males, 33 females; mean age: 28.3±8.