PPAR- Activation Prevents Septic Cardiac Dysfunction via Inhibition of Apoptosis and Necroptosis.

Sepsis-induced cardiac dysfunction remains one of the major causes of death in intensive care units. Overwhelmed inflammatory response and unrestrained cell death play critical roles in sepsis-induced cardiac dysfunction. Peroxisome proliferator-activated receptor- (PPAR-) has been proven to be cardioprotective in sepsis.