SARS-CoV-2 and HCoV-OC43 regulate host m6A modification via activation of the mTORC1 signaling pathway to facilitate viral replication.

N6-methyladenosine (m6A) is the most prevalent post-transcriptional modification in eukaryotic RNA and is also present in various viral RNAs, where it plays a crucial role in regulating the viral life cycle. However, the molecular mechanisms through which viruses regulate host RNA m6A methylation are not fully understood. In this study, we reveal that SARS-CoV-2 and HCoV-OC43 infection enhance host m6A modification by activating the mTORC1 signaling pathway.

P300-mediated NEDD4 acetylation drives ebolavirus VP40 egress by enhancing NEDD4 ligase activity.

The final stage of Ebola virus (EBOV) replication is budding from host cells, where the matrix protein VP40 is essential for driving this process. Many post-translational modifications such as ubiquitination are involved in VP40 egress, but acetylation has not been studied yet. Here, we characterize NEDD4 is acetylated at a conserved Lys667 mediated by the acetyltransferase P300 which drives VP40 egress process.

Fomesafen impacts bacterial communities and enzyme activities in the rhizosphere.

Fomesafen, a long-lived protoporphyrinogen-oxidase inhibitor, specially developed for post-emergence control of broad-leaf weeds, is used widely in soybean fields in northern China (Dayan and Duke, 2010). The impact of fomesafen on microbial communities in rhizosphere soils, however, is unknown. In this study we examined fomesafen degradation as well as its effects in the rhizosphere of soybean plants grown in a greenhouse.

High efficiency green OLEDs based on homoleptic iridium complexes with steric phenylpyridazine ligands.

A series of steric phenylpyridazine based homoleptic iridium(iii) complexes (1-3) have been synthesized with novel one-pot methods. Single X-ray structural analyses are conducted on complexes 1 and 2 to reveal their coordination arrangement. These complexes exhibit a very strong green phosphorescence emission with high quantum yields of over 64%.

Increased ZNF84 expression in cervical cancer.

Purpose: Little is known about ZNF84 gene. This study aims to investigate ZNF84 expression in cervical cancer (CC) and the effects of ZNF84 on CC.

Materials And Methods: Cervical cancer tissue specimens were collected from The First People's Hospital of Foshan.

Synergistic Effects of Ag Nanoparticles/BiVMoO with Enhanced Photocatalytic Activity.

In recent years, BiVO has drawn much attention as a novel photocatalyst given its excellent ability to absorb visible light. This work reports the development of Ag-modified BiVMoO composites through a facile hydrothermal synthesis with the subsequent photoinduced reduction of Ag at almost neutral pH conditions. Metallic Ag nanoparticles were deposited on the (040) facet of Mo-doped BiVO powders.

Morphological study of mechanoreceptors in collateral ligaments of the ankle joint.

Background: The aim of this study was to analyze the pattern and types of sensory nerve endings in ankle collateral ligaments using histological techniques, in order to observe the morphology and distribution of mechanoreceptors in the collateral ligaments of cadaver ankle joint, and to provide the morphological evidence for the role of the ligament in joint sensory function.

Methods: Twelve lateral collateral ligaments including anterior talofibular ligament (ATFL; n = 6), posterior talofibular ligament (PTFL; n = 6), and calcaneofibular ligament (CFL; n = 6) were harvested from six fresh frozen cadavers. The ligaments were embedded in paraffin, sectioned at 4 μm, and then stained using a modified gold-chloride staining methods.