Publications by authors named "Shixiong Yang"

Article Synopsis
  • - The study aimed to evaluate how effective nanopore sequencing technology is for diagnosing tuberculous meningitis (TBM) using cerebrospinal fluid samples from patients.
  • - Compared to traditional methods like acid-fast staining and culture, nanopore sequencing had a sensitivity of 43.30% and an area under the ROC curve of 0.661, indicating better performance overall.
  • - When nanopore sequencing was used alongside imaging techniques, it achieved the best diagnostic results with increased sensitivity, specificity, and predictive values, showing its potential as a reliable tool for TBM diagnosis.
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This paper uses the GJRSK model to estimate the high-order moments of energy (oil, natural gas, and coal), the carbon market, and tourism stocks. Then, it utilizes a novel TVP-VAR time-frequency connectedness approach to examine higher-order moments spillovers among them. The results show a strong connectedness among the three markets.

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Background: The co-infection of human immunodeficiency virus type 1 (HIV-1) and tuberculosis poses a lethal threat. Currently, our understanding of the altered immune responses and diverse immune cell subpopulations triggered by dual pathogen infections remains inadequate.

Methods: We utilized single-cell RNA sequencing data from the Gene Expression Omnibus database and the China National GeneBank Nucleotide Sequence Archive to study peripheral blood mononuclear cells from individuals infected with HIV-1 and those co-infected with Mycobacterium tuberculosis (Mtb)/HIV.

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Objective: To develop and validate a machine learning model for predicting mortality-associated prognostic factors in order to reduce in-hospital mortality rates among HIV/AIDS patients with Cryptococcus infection in Guangxi, China.

Methods: This retrospective prognostic study included HIV/AIDS patients with cryptococcosis in the Fourth People's Hospital of Nanning from October 2011 to June 2019. Clinical features were extracted and used to train ten machine learning models, including Logistic Regression, KNN, DT, RF, Adaboost, Xgboost, LightGBM, Catboost, SVM, and NBM, to predict the outcome of HIV patients with cryptococcosis infection.

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Article Synopsis
  • Recurrent opportunistic infections in severely immunosuppressed AIDS patients persist as a challenge, leading to the development of a new therapy called allogeneic adoptive immune therapy (AAIT) alongside traditional antiretroviral therapy (ART).
  • A phase 2a trial showed that AAIT improved CD4+ T cell recovery compared to ART alone, without increasing adverse events.
  • The study found that factors like donor/recipient sex mismatch significantly influenced the likelihood of achieving an immunological response, indicating AAIT's potential as a valuable treatment for this patient group while highlighting the need for further research to better understand its mechanisms and optimize its use.
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This study comprehensively assesses spatial distribution, pollution levels, and potential sources of heavy metal(loid)s in surface sediments across multiple river systems along the coastal area of the East China Sea. Copper in Qiantang River and Xiangshan Bay showed higher concentations and exceeded the threshold effect value, while the higher content of Lead was mainly found in the Saijiang River, Oujiang River, and Minjiang River. Heavy metal(loid)s in the alluvium of Qiantang River, Jiaojiang River, and Yangtze River showed low to moderate pollution levels, with Cd posing the highest ecological risk, followed by Hg.

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The impact of climate warming on soil microbial communities can significantly influence the global carbon cycle. Coastal wetlands, in particular, are susceptible to changes in soil microbial community structure due to climate warming and the presence of invasive plant species. However, there is limited knowledge about how native and invasive plant wetland soil microbes differ in their response to warming.

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Background: The era of high throughput sequencing offers new paths to identifying species boundaries that are complementary to traditional morphology-based delimitations. De novo species delimitation using traditional or DNA super-barcodes serve as efficient approaches to recognizing putative species (molecular operational taxonomic units, MOTUs). Tea plants (Camellia sect.

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The purpose of this study is to evaluate the cell lines seen on esophagogastoduodenoscopy (EGD) of children who have difficulties feeding, esophageal fistula, and asthma that has some histologic abnormalities.  This is a study that looked back at the medical records of 100 children whose cells had been surgically restored after being impacted by EA or TEF. A review of the instrumental tests that were carried out at our facility has been conducted in order to identify any lingering anatomic or functional abnormalities of the airways and gastrointestinal system that would explain the pulmonary clinical images.

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The development of a reasonable method for predicting heavy metals (HMs) pollution in atmospheric particulate matter (PM) remains challenging. This paper presents an elution-filtration method to collect PM from the surface of Osmanthus fragrans in a very clean area (Guiyang, China). The aim is to evaluate the effectiveness of biomagnetic leaf monitoring as a simple and rapid method for assessing HMs pollution in clean cities.

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Gene tree discordance is a significant legacy of biological evolution. Multiple factors can result in incongruence among genes, such as introgression, incomplete lineage sorting (ILS), gene duplication or loss. Resolving the background of gene tree discordance is a critical way to uncover the process of species diversification.

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Article Synopsis
  • The study focused on analyzing genetic subtypes of HIV and the rate of drug resistance in newly diagnosed HIV-infected men aged 50 or older in Guangxi from January to June 2020.
  • Out of 615 participants, the majority were infected with the HIV subtypes CRF01_AE, CRF07_BC, and CRF08_BC, with a total of 22 patients showing resistance to at least one type of antiretroviral drug.
  • The research found that pretreatment resistance to non-nucleoside reverse transcriptase inhibitors (NNRTIs) was more common than to nucleoside reverse transcriptase inhibitors (NRTIs), indicating a generally low prevalence of drug resistance among this population
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Understanding the processes determining the composition of alluvial pollen assemblages and its relationship with watershed vegetation is a prerequisite for alluvial palynological study. Palynological analysis of a total of 45 river water samples collected from the middle reaches of the Yellow River and its major tributaries, identifies the distribution patterns, possible sources of pollen and relationship with the catchment vegetation. The results reveal that the pollen assemblages in the middle reaches of the Yellow River is dominated by herbaceous taxa, and the pollen is mainly derived from fluvial sources.

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Background And Aims: Theaceae, with three tribes, nine genera and more than 200 species, are of great economic and ecological importance. Recent phylogenetic analyses based on plastomic data resolved the relationships among the three tribes and the intergeneric relationships within two of those tribes. However, generic-level relationships within the largest tribe, Theeae, were not fully resolved.

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Human immunodeficiency virus (HIV) is a single-stranded RNA virus that can weaken the body's cellular and humoral immunity and is a serious disease without specific drug management and vaccine. This study aimed to evaluate the epidemiologic characteristics and transmissibility of HIV. Data on HIV follow-up were collected in Nanning City, Guangxi Zhuang Autonomous, China.

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Pneumonia is currently one of the leading causes of death in children. Increased susceptibility to pneumonia may be due to their decreased immunity. One of the reasons for the decrease in immunity is zinc deficiency.

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Early and effective identification of severe coronavirus disease 2019 (COVID-19) may allow us to improve the outcomes of associated severe acute respiratory illness with fever and respiratory symptoms. This study analyzed plasma concentrations of heat shock protein gp96 in nonsevere (including mild and typical) and severe (including severe and critical) patients with COVID-19 to evaluate its potential as a predictive and prognostic biomarker for disease severity. Plasma gp96 levels that were positively correlated with interleukin-6 (IL-6) levels were significantly elevated in COVID-19 patients admitted to the hospital but not in non-COVID-19 patients with less severe respiratory impairment.

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The chemical composition and hardness of bovine bone, porcine bone, chicken bone, and rabbit bone were compared, as well as the influence of nanoprocessing on the physicochemical characteristics of these bone powders. A series of nanofabrication processes led to an increase in bone minerals and the loss of protein and fat. The hardness of softened bovine bone was still the largest, whereas chicken and rabbit bones were relatively soft.

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Article Synopsis
  • The study analyzed 478 COVID-19 patients from four major cities in China (excluding Wuhan) to understand the epidemiological and clinical characteristics of the virus during the pandemic.
  • The average patient age was 46.9 years, with common symptoms including fever, cough, and fatigue; 65.5% of cases were indigenous, while 34.5% were imported.
  • The findings revealed that imported cases differed significantly from indigenous ones in severity and symptoms, highlighting the shift from imported to local infections and emphasizing the importance of controlling spread in local areas.
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Background: A pandemic caused by SARS-CoV-2 infection (COVID-19) has rapidly spread across the globe. Although many articles have established the clinical characteristics of adult COVID-19 patients so far, limited data are available for children. The aim of this study was to reveal the clinical features, laboratory findings and nucleic acid test results of ten pediatric cases.

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Understanding pollen transport pathways and dispersal mechanism from the land to sea is a prerequisite for marine palynological study. Palynological analysis of 164 surface sediment samples in Liaodong Bay, and 39 analogous surface alluvium samples from its five inflowing rivers, identifies the distribution patterns, pathways and possible sources of pollen and spores. The results show that pollen and spore assemblages in surface sediments are well correlated to regional vegetation distribution, and the variations of pollen assemblage in different parts of Liaodong Bay reflected local vegetation changes along the coast.

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