Cullin3 aggravates the inflammatory response of periodontal ligament stem cells via regulation of SHH signaling and Nrf2.

It is found that the activation of Sonic Hedgehog (SHH) signaling pathway is related to the degree of inflammation in patients suffering from periodontitis. Cullin3 (CUL3), an important ubiquitin ligase, can control SHH signaling. In this study, we were dedicated to clarify the roles of SHH and CUL3 in -LPS (Pg-LPS)-treated periodontal ligament stem cells (PDLSCs).

[Study on the mechanism of endothelial progenitor cells in periodontal revascularization during orthodontic tooth movement].

Purpose: To investigate the mechanism of endothelial progenitor cells(EPCs) bone remodeling during orthodontic tooth movement.

Methods: Experimental tooth movement model was established. EPCs were isolated, cultured, and labeled with 10 μmol/L Brdu and injected into rats through tail vein to observe the distribution in periodontal tissue.

Effects of Quartz Splint Woven fiber periodontal fixtures on evaluating masticatory efficiency and efficacy.

Masticatory efficiency is altered by mobile teeth resulting from periodontal disease. The goal of our study was to investigate changes before and after fixation of mobile teeth with a Quartz Splint Woven high-strength quartz fiber splint and evaluate the fixation effect.Forty-two patients with chronic severe periodontal disease and 2 to 3 degree tooth mobility underwent fixation with Quartz Splint Woven quartz fiber splints.

[Use of visual analogue scale and pain-related factors to evaluate the impact of different orthodontic forces on human dental pulp in patients who underwent fixed dental treatment].

Purpose: To investigate the role of visual analogue scale (VAS) and pain-related factors, like tumor necrosis factor-alpha (TNF-α), interleukin-8 (IL- 8), interleukin-6 (IL-6) and interleukin-1 beta (IL-1β) in evaluation of the impact of different orthodontic forces on human dental pulp in patients who underwent fixed dental treatment.

Methods: From January 2014 to April 2015, 156 patients with maxillary bilateral premolar treated with tooth fixed were randomly divided into 4 groups, 42 patients in control group, 40 patients in 100 g-force group, 40 patients in 150 g-force group, and 39 in 200 g-force group. VAS was used to evaluate before and after removed.