The temporal-insula type of temporal plus epilepsy patients with different postoperative seizure outcomes have different cerebral blood flow patterns.

Purpose: This study retrospectively analyzed preoperative arterial spin labeling (ASL) perfusion MRI data of patients with the temporal-insula type of temporal plus epilepsy (TI-TPE). We aimed to investigate the differences in presurgical cerebral blood flow (CBF) changes in TI-TPE patients with different surgical outcomes.

Method: A total of 48 TI-TPE patients confirmed by SEEG were meticulously reviewed for this study.

Three new species of Polleniidae (Diptera) from China.

Liu, Li & Yao, , Liu, Li & Yao, and Liu, Li & Yao, from the Guangxi Zhuang Autonomous Region and Chongqing are described and illustrated. Keys to species of the genera and from China are provided. Photographs of the habitus and male genitalia of the new species are also provided.

Associations between sleep traits and colorectal cancer: a mendelian randomization analysis.

Background: Although many researches have shown a relationship between sleeping habits and the risk of developing colorectal cancer (CRC), there is a lack of data from randomized controlled trials (RCTs) to support this point. Hence, this study used Mendelian randomization (MR) to robustly assess whether five primary sleep characteristics are directly linked with the risk of CRC occurrence.

Methods: In the performed study, the main Mendelian randomization analysis was conducted using approaches such as Inverse Variance Weighting (IVW), MR Egger, and weighted median method.

Exfoliated Molybdenum Disulfide Nanosheet Networks as Sensing Materials for Nitrogen Dioxide Detection.

Nitrogen dioxide (NO) is a gaseous air pollutant linked to respiratory and cardiovascular diseases and environmental problems such as acid rain and tropospheric ozone formation. Reference instruments for measuring NO are expensive, highlighting the need to develop low cost sensor technologies for wider scale monitoring of this critical pollutant. Here, we report the development of a scalable sensor using electrochemically exfoliated 2D molybdenum disulfide (MoS) networks.

Extracting the Temperature Dependence of Both Nanowire Resistivity and Junction Resistance from Electrical Measurements on Printed Silver Nanowire Networks.

Printed networks of nanoparticles (e.g., nanodots, nanowires, nanosheets) are important for a range of electronic, sensing and energy storage applications.

Quality of Life and Functional Outcomes in Patients With Locally Advanced Rectal Cancer Receiving Total Neoadjuvant Therapy Versus Concurrent Chemoradiation Therapy: An Analysis of the STELLAR Trial.

Purpose: To explore differences in the effects of total neoadjuvant therapy (TNT) and preoperative concurrent chemoradiation therapy (CRT) on quality of life and functional outcomes in patients with locally advanced rectal cancer.

Methods And Materials: In the study, 591 patients with distal or middle-third, clinical primary tumor stage cT3 to 4 and/or regional lymph node-positive rectal cancer were randomly assigned (1:1) to receive short-term radiation therapy (25 Gy in 5 fractions) followed by 4 cycles of CAPOX (TNT group, n = 297) or standard CRT (50 Gy in 25 fractions concurrently with oral capecitabine) (CRT group, n = 294) before surgery. After a 6-year follow-up, the surviving patients were sent surveys, including the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ)-C30, EORTC QLQ-CR29, and Wexner incontinence score questionnaires.

Ferroelectric/Electric-Double-Layer-Modulated Synaptic Thin Film Transistors toward an Artificial Tactile Perception System.

Tactile sensation and recognition in the human brain are indispensable for interaction between the human body and the surrounding environment. It is quite significant for intelligent robots to simulate human perception and decision-making functions in a more human-like way to perform complex tasks. A combination of tactile piezoelectric sensors with neuromorphic transistors provides an alternative way to achieve perception and cognition functions for intelligent robots in human-machine interaction scenarios.

Three-arm polyrotaxanes with multidirectional molecular motions as the nanocarrier for nitric oxide-enhanced photodynamic therapy against bacterial biofilms in septic arthritis.

Bacterial biofilms are one of the major contributors to the refractoriness of septic arthritis. Although nitric oxide (NO)-enhanced photodynamic (PDT) therapy has been involved in biofilm eradication, the anti-biofilm efficacy is usually hindered by the short half-life and limited diffusion distance of active molecules. Herein, we report a three-arm structure using the photosensitive core chlorin e6 to integrate three α-cyclodextrin (α-CD) polyrotaxane chains as the supramolecular nanocarrier of NO-enhanced PDT therapy, in which NO was loaded on the cationic rings (α-CDs).

Noncontact Perception of Thin-Film Transistors by the Synergy of Both Capacitive and Electrostatic Induction Mechanisms.

In recent years, the rapid expansion of research and application of the Internet of Things and wearable electronics has prompted the development of a variety of sensors to perceive physical or chemical information from both the human body and the environment, among which the proximity sensor is a kind of noncontact sensor used to detect the approach of a target and thus exhibits promising applications in human-machine interactions. Thin-film transistors are one type of key components in modern electronics and have been further developed as electrostatic-induction-type proximity sensors to perceive the approach of electrically charged objects. However, they are immune to the approach of a zero-potential object.

In Situ Nucleosome Assembly for Single-Molecule Correlative Force and Fluorescence Microscopy.

Nucleosomes constitute the primary unit of eukaryotic chromatin and have been the focus of numerous informative single-molecule investigations regarding their biophysical properties and interactions with chromatin-binding proteins. Nucleosome reconstitution on DNA for these studies typically involves a salt dialysis procedure that provides precise control over the placement and number of nucleosomes formed along a DNA tether. However, this protocol is time-consuming and requires a substantial amount of DNA and histone octamers as inputs.

Differential dynamics specify MeCP2 function at nucleosomes and methylated DNA.

Methyl-CpG-binding protein 2 (MeCP2) is an essential chromatin-binding protein whose mutations cause Rett syndrome (RTT), a severe neurological disorder that primarily affects young females. The canonical view of MeCP2 as a DNA methylation-dependent transcriptional repressor has proven insufficient to describe its dynamic interaction with chromatin and multifaceted roles in genome organization and gene expression. Here we used single-molecule correlative force and fluorescence microscopy to directly visualize the dynamics of wild-type and RTT-causing mutant MeCP2 on DNA.

Neuronal rhythmicity and cortical arousal in a mouse model of absence epilepsy.

Objectives: Absence seizures impair psychosocial function, yet their detailed neuronal basis remains unknown. Recent work in a rat model suggests that cortical arousal state changes prior to seizures and that single neurons show diverse firing patterns during seizures. Our aim was to extend these investigations to a mouse model with studies of neuronal activity and arousal state to facilitate future fundamental investigations of absence epilepsy.

Evaluating and diagnosing ecosystem health of the "three-lake" watershed in Yuxi, Yunnan, China from 2010 to 2020 by PSR-KDE.

To carry out the diagnosis and evaluation of the ecosystem health in Yuxi three-lake watershed, this paper presents the changing trend of its health state, and predicts the future development. This also provides ideas for maintaining the regional ecosystem health, and then gradually improves the ecological environment quality. Taking Fuxian Lake, Qilu Lake and Xingyun Lake (the three-lake watershed) in Yuxi City, Yunnan Province, Southwest China as the research object, a model combining pressure-state-response and kernel density estimation (PSR-KDE) adopts to diagnose and evaluate the ecosystem health of the "three lake" watershed from 2010 to 2020, and the distribution map of ecosystem health index has obtained by the evaluation indexes integration based on GIS spatial analysis.

Transformer with difference convolutional network for lightweight universal boundary detection.

Although deep-learning methods can achieve human-level performance in boundary detection, their improvements mostly rely on larger models and specific datasets, leading to significant computational power consumption. As a fundamental low-level vision task, a single model with fewer parameters to achieve cross-dataset boundary detection merits further investigation. In this study, a lightweight universal boundary detection method was developed based on convolution and a transformer.

Knot Architecture for Biocompatible and Semiconducting 2D Electronic Fiber Transistors.

Wearable devices have generally been rigid due to their reliance on silicon-based technologies, while future wearables will utilize flexible components for example transistors within microprocessors to manage data. Two-dimensional (2D) semiconducting flakes have yet to be investigated in fiber transistors but can offer a route toward high-mobility, biocompatible, and flexible fiber-based devices. Here, the electrochemical exfoliation of semiconducting 2D flakes of tungsten diselenide (WSe) and molybdenum disulfide (MoS) is shown to achieve homogeneous coatings onto the surface of polyester fibers.

Incomplete transcripts dominate the Mycobacterium tuberculosis transcriptome.

Mycobacterium tuberculosis (Mtb) is a bacterial pathogen that causes tuberculosis (TB), an infectious disease that is responsible for major health and economic costs worldwide. Mtb encounters diverse environments during its life cycle and responds to these changes largely by reprogramming its transcriptional output. However, the mechanisms of Mtb transcription and how they are regulated remain poorly understood.

All-fiber hectowatt radially polarized laser system.

A high-power all-fiber radially polarized laser system is demonstrated, in which an integrated nanograting mode convertor (S-wave plate) is used for the generation of radially polarized beam. Experimentally, a 1-W radially polarized beam was used as the seed laser, whose mode purity and mode extinction ratio (MER) were 96.5% and 98.