Biomarkers of lipid metabolism in gastric cancer: a case control study.

Background: The aim of this study was to explore the correlation between biomarkers of lipid metabolism and gastric cancer.

Methods: 1120 gastric cancer patients and 1134 health examiners enrolled in this study. The clinic data and serum lipid level, including Total cholesterol (TC), Triglyceride (TG), Low-density lipoprotein cholesterol (LDL-C) and High-density lipoprotein cholesterol (HDL-C), were collected.

Characteristics and whole-genome analysis of a novel Pseudomonas syringae pv. tomato bacteriophage D6 isolated from a karst cave.

Pseudomonas syringae is a gram-negative plant pathogen that infects plants such as tomato and poses a threat to global crop production. In this study, a novel lytic phage infecting P. syringae pv.

LncRNA DGUOK-AS1 Promotes Cell Progression in Lung Squamous Cell Carcinoma by Regulation of miR-653-5p/SLC6A15 Axis.

Long noncoding RNA (lncRNA) plays a key role in regulating cancer development. LncRNA deoxyguanosine kinase antisense RNA 1 (DGUOK-AS1) has been reported as a promoter in tumor. The work was designed to further investigate the mechanism of action of DGUOK-AS1 in lung squamous cell carcinoma (LUSC).

Comparison between thoracic low-dose computed tomography and conventional-dose computed tomography in evaluating anemia: A preliminary study in a Chinese screening cohort.

Purpose: To investigate and evaluate the value of thoracic low dose computed tomography (LDCT) scan in the diagnosis of anemia.

Materials And Methods: 661 patients who received thoracic computed tomography (CT) examination and underwent a peripheral blood examination were retrospectively included. 341 patients underwent conventional dose CT (CDCT), and 320 patients underwent LDCT.

sp. nov., a novel actinobacterium isolated from sediment of karst cave.

A novel, Gram-stain-positive, aerobic, non-endospore-forming, non-motile and rod-shaped bacterium designated PO-11 was isolated from sediment of karst cave collected in Libo county, Guizhou Province, PR China. The isolate grew optimally on R2A agar at 25 °C, pH 8.0 and with 0.

THE INFLUENCE OF LOW-DOSE OCCUPATIONAL RADIATION EXPOSURE ON PERIPHERAL BLOOD CELLS IN A COHORT OF CHINESE MEDICAL RADIATION WORKERS.

Objectives: The study aims to assess the change of peripheral blood cell numbers following protracted low-dose radiation exposure among medical radiation workers.

Methods: A cohort of 375 Chinese medical workers were followed for 5 years (2015-19) and recorded the changes in blood cells and cumulative doses. T-test, least significant difference-T test, variance analysis and correlation analysis were utilized in this study.

Actively tunable multi-band terahertz perfect absorber due to the hybrid strong coupling in the multilayer structure.

In this work, we propose a multi-band terahertz perfect absorber employing the topological photonic crystal combined with VO and graphene. The hybrid strong coupling among the topological photonic state, the Tamm plasmon polaritons excited around the interfaces of VO and graphene results in the three perfect absorption bands. Benefiting from the reversible insulator-metal phase transition of VO and the tunable Fermi level of graphene, it can actively switch among no absorption, single-band, dual-band and multi-band absorptions around 1THz, with the absorption frequencies tunable as well.

The mutation landscape of multiple cancer predisposition genes in Chinese familial/hereditary breast cancer families.

Objective: Approximately 5%-10% of breast cancer (BC) patients display familial traits that are genetically inherited among the members of a family. The purpose of this study was to profile the germline mutations in 43 genes with different penetration rates and their correlations with phenotypic traits in Chinese familial BC families.

Methods: Ion Torrent S5™-based next generation sequencing was conducted on 116 subjects from 27 Chinese familial BC families.

Actively tunable bi-functional metamirror in a terahertz band.

In this work, we have proposed an actively tunable bi-functional metamirror based on a bi-layer graphene structure. The metamirror acts as a spin-selective absorber under circularly polarized incidence, which behaves as nearly perfect absorption and reflection for right and left circularly polarized waves, respectively, leading to giant circular dichroism. On the other hand, it is a polarization converter under linearly polarized incidence, which reflects the linearly polarized wave into a left circularly polarized wave.

Tuning of the polariton modes induced by longitudinal strong coupling in the graphene hybridized DBR cavity.

In this Letter, we construct a graphene hybridized distributed Bragg reflector (DBR) cavity, where spatially longitudinal strong coupling occurs between the Tamm plasmon polaritons (TPPs) existing around the graphene layer and the cavity mode (CM) existing in the DBR cavity. As a result, two hybrid polariton modes emerge, which contain both the TPP and the CM components. In the simulation, we demonstrate that the resonant frequencies and the damping rates of the polariton modes can be actively tuned by the graphene Fermi level and the incident angle of light.

The Association Between Metabolic Syndrome and Gastric Cancer in Chinese.

Metabolic syndrome (MetS) play a carcinogenic role in variety of cancers and influence the prognosis of cancer patients both systemically and hormonally. The data of clinicopathologic features and MetS of 808 gastric cancer patients and 1,146 randomly healthy controls were analyzed retrospectively. Higher TG level, lower HDL-C level and higher hypertension frequency were observed in all gastric cancer patients when compared with healthy controls.

Tumor-infiltrating Treg, MDSC, and IDO expression associated with outcomes of neoadjuvant chemotherapy of breast cancer.

Background: Regulatory T cells(Tregs) and myeloid-derived suppressor cells(MDSCs) represent two immunosuppressive cell populations that are important in the establishment and maintenance of cancer immune tolerance. MDSCs can express IDO and promote immune tolerance via expansion of Treg cell.

Method: We use needle biopsy breast cancer tissues prior to neoadjuvant chemotherapy(NCT) staining for CD33, Foxp3 and IDO by immunohistochemistry to evaluate whether they were correlated with subsequent treatment responses in breast cancer.

Indoleamine-2,3-dioxygenase and Interleukin-6 associated with tumor response to neoadjuvant chemotherapy in breast cancer.

Purpose: Indoleamine-2,3-dioxygenase (IDO) and Interleukin-6 (IL-6) contribute to poor therapeutic effects, tumor relapse and aggressive tumor growth. IDO and IL-6 incorporate a positive feedback signal loop to maintain IDO and IL-6 constitutive expression and facilitate tumor progression.

Results: IDO expression was associated with IL-6 expression and plasma IL-6 level (0.

New Approaches for Biaryl-Based Phosphine Ligand Synthesis via P═O Directed C-H Functionalizations.

Given the important influence of phosphine ligands in transition metal-catalyzed reactions, chemists have searched for straightforward and efficient methodologies for the synthesis of diverse phosphine ligands. Although significant progress has been made in this aspect over the past decades, the development of new phosphorus-containing ligands with properties superior to their predecessors remains a central task for chemists. Recently, researchers have demonstrated that biphenyl monophosphine ligands function as highly efficient ligands for transition-metal-catalyzed organic transformations, especially for reactions where chelating bisphosphine ligands cannot be used.

IDO1: An important immunotherapy target in cancer treatment.

Indoleamine 2,3-dioxigenase 1 (IDO1) acts in pathogenic inflammatory processes and engender immune tolerance to tumor antigens. IDO1 can decrease the tryptophan and produce a series of toxic kynurenine metabolites to promote the immune toleration via GCN2 pathway, mTOR pathway, toxic effect of kynurenine and favoring differentiation of Tregs. IDO1 can be induced in most human cells, especially APCs and cancer cells through canonical and non-canonical NF-κB and Jak/STAT pathways, as well as PKC and TGF-β signaling pathways.

P(O)R-Directed Enantioselective C-H Olefination toward Chiral Atropoisomeric Phosphine-Olefin Compounds.

An effective synthesis of chiral atropoisomeric biaryl phosphine-olefin compounds via palladium-catalyzed enantioselective C-H olefination has been developed for the first time. The reactions are operationally simple, tolerate wide functional groups, and have a good ee value. Notably, P(O)R not only acts as the directing group to direct C-H activation in order to make a useful ligand but also serves to facilitate composition of the product in a useful manner in this transformation.

1.1 MW peak power in doubly QML composite Nd:YVO4/Nd:YVO4/Nd:YVO4/KTP sub-nanosecond green laser with EO and Bi-GaAs.

By simultaneously employing electro-optic (EO) modulator and Bi-doped GaAs, dual-loss-modulated Q-switched and mode-locked (QML) multi-segment composite Nd:YVO4/Nd:YVO4/Nd:YVO4/KTP sub-nanosecond green laser is demonstrated with low repetition rate and high peak power. When the incident pump power is up to 6.93 W, only one mode-locking pulse underneath a Q-switching envelope is generated with sub-nanosecond pulse duration at one kilohertz repetition rate.

The effect of antisense inhibitor of miRNA 106b∼25 on the proliferation, invasion, migration, and apoptosis of gastric cancer cell.

Accumulating data has demonstrated that miRNA 106b∼25, which are composed of the highly conserved miRNA 106b, miRNA 93, and miRNA 25, play carcinogenic roles in cancers. We investigated the expression of miRNA 106b∼25 in gastric cancer cells (SGC 7901, MGC 803, BGC 823) and normal gastric epithelial cell then inhibited miRNA 106b∼25 expression via transiently transfecting their antisense inhibitor. After miRNA 106b∼25 cluster was inhibited, MTT, Scratch test, Transwell invasion test, and flow cytometry were applied to investigate the proliferation, invasion, migration, cell cycle, and apoptosis of gastric cancer cell.

The selective estrogen receptor modulators in breast cancer prevention.

Backgrounds: Persistently increased blood levels of estrogens are associated with an increased risk of breast cancer. Selective estrogen receptor modulators (SERMs) are a class of compounds that act on the estrogen receptor (ER).

Methods: Several clinical trials have demonstrated the effectiveness of its prophylactic administration.

Dearomatization of Indoles via Palladium-Catalyzed Allylic C-H Activation.

The first Pd-catalyzed allylic dearomatization of substituted indoles triggered by C-H bond activation is reported. The presence of a catalytic amount of 2,5-DMBQ is proven to be a key factor for the high yield. This one-pot tandem allylic C-H activation/dearomatization sequence provides a straightforward access to 3,3-disubstituted indolines.

Experimental and theoretical investigation on passively Q-switched laser action in c-cut Nd:MgO:LiNbO₃.

The performance of a diode-pumped c-cut Nd:MgO:LiNbO3 laser at 1093 nm was demonstrated. Under an absorbed pump power of 7.450 W, a maximum continuous wave output power of 1.

Role of microRNA-93 in regulation of angiogenesis.

Angiogenesis is essential for a wide variety of physiological and pathological processes. To date, many angiogenic microRNAs (miRNAs) have been identified and several of them were further investigated to elucidate the mechanisms of specific miRNAs in regulating angiogenesis. In recent studies concerning tumor and ischemia, the miRNA-93 had been demonstrated to be able to modulate angiogenesis in different molecular pathways.