High-dose vitamin C as a metabolic treatment of cancer: a new dimension in the era of adjuvant and intensive therapy.

The anti-cancer mechanism of High-dose Vitamin C (HDVC) is mainly to participate in the Fenton reaction, hydroxylation reaction, and epigenetic modification, which leads to the energy crisis, metabolic collapse, and severe peroxidation stress that results in the proliferation inhibition or death of cancer cells. However, the mainstream view is that HDVC does not significantly improve cancer treatment outcomes. In clinical work and scientific research, we found that some drugs or therapies can significantly improve the anti-cancer effects of HDVC, such as PD-1 inhibitors that can increase the anti-cancer effects of cancerous HDVC by nearly three times.

Hemolysis attributed to high dose vitamin C: Two case reports.

Background: High-dose vitamin C treatment (HVCT) can reduce the adverse effect of chemotherapy and enhance the effect of antitumor therapy, which has been considered one of the safest alternative treatments. However, the severity of its adverse effects may have been underestimated. The most serious adverse effect is hemolysis, which may result in acute kidney injury or death.

Network pharmacology and molecular docking technology for exploring the effect and mechanism of high-dose vitamin c on ferroptosis of tumor cells: A review.

To investigate the mechanism by which high-dose vitamin C (HVC) promotes ferroptosis in tumor cells via network pharmacology, vitamin C-related and ferroptosis-related targets were obtained from the PharmMapper and GeneCards databases, respectively, and their common targets were compared using the Venn diagram. Common targets were imported into the STRING database for protein-protein interaction analysis, and core targets were defined. Core targets were enriched for Gene Ontology terms and Kyoto Encyclopedia of Genes and Genomes pathways using the R language packages.

Study on the Cooling Effect of Asphalt Pavement Blended with Composite Phase Change Materials.

To explore the cooling effect of phase change materials (PCM) on asphalt pavement, a numerical model of the coupled heat transfer process of a typical monolithic subgrade of the G7 Expressway in the eastern Tianshan mountain area was developed. Three types of paraffin materials (OP55E, OP52E, OP47E) were mixed in a 4:3:3 volume ratio and blended into the asphalt upper layer and overall asphalt layer at volume ratios of 5%, 10%, 15% and 20%. The cooling effect of different PCM addition schemes was simulated and analyzed, and the frequency and duration of asphalt pavement high temperature operation status were also measured.

The relationship between birthing related factors and maternal breastfeeding confidence in China.

Problem: The relationship between birthing related factors and breastfeeding confidence remain unknown among Chinese mothers.

Background: Breastfeeding confidence in the early postpartum period is an important predictor of breastfeeding duration. There are many postpartum and socio-demographic factors that have been linked to breastfeeding confidence.