The 100 top-cited articles in menopausal syndrome: a bibliometric analysis.

Background: Significant scientific research has been conducted concerning menopausal syndrome(MPS), yet few bibliometric analyses have been performed. Our aim was to recognise the 100 most highly cited published articles on MPS and to analytically evaluate their key features.

Methods: To identify the 100 most frequently cited articles, a search was conducted on Web of Science using the term 'menopausal syndrome'.

Crosstalk among podocytes, glomerular endothelial cells and mesangial cells in diabetic kidney disease: an updated review.

Diabetic kidney disease (DKD) is a long-term and serious complication of diabetes that affects millions of people worldwide. It is characterized by proteinuria, glomerular damage, and renal fibrosis, leading to end-stage renal disease, and the pathogenesis is complex and involves multiple cellular and molecular mechanisms. Among three kinds of intraglomerular cells including podocytes, glomerular endothelial cells (GECs) and mesangial cells (MCs), the alterations in one cell type can produce changes in the others.

Moxibustion's protective role against atherosclerosis: Inhibition of Ca overload-triggered oxidative stress and inflammatory response via P2Y12/PI3K/AKT pathway.

Objective: This study aims to investigate the protective mechanism of moxibustion in combating atherosclerosis (AS).

Methods: Apolipoprotein E (ApoE)-deficient mice, aged 8 weeks, were randomly assigned into four groups: the model group (n = 6), SC79 group (n = 6), moxibustion group (n = 6), and moxibustion+SC79 group (n = 6). All mice were fed with a high-fat diet (HFD).

Gut microbial beta-glucuronidase: a vital regulator in female estrogen metabolism.

A growing amount of evidence has supported that gut microbiota plays a vital role in the reproductive endocrine system throughout a woman's whole life, and gut microbial β-glucuronidase (gmGUS) is a key factor in regulating host estrogen metabolism. Moreover, estrogen levels also influence the composition as well as the diversity of gut microbiota. In normal condition, the gmGUS-estrogen crosstalk maintains body homeostasis of physiological estrogen level.

Inflammation-Related Epigenetic Modification: The Bridge Between Immune and Metabolism in Type 2 Diabetes.

T2DM, as a typical metabolic inflammatory disease, is under the joint regulation of environmental factors and genetics, combining with a variety of epigenetic changes. Apart from epigenetic changes of islet β cells and glycometabolic tissues or organs, the inflammation-related epigenetics is also the core pathomechanism leading to β-cell dysfunction and insulin resistance. In this review, we focus on the epigenetic modification of immune cells' proliferation, recruitment, differentiation and function, providing an overview of the key genes which regulated by DNA methylation, histone modifications, and non-coding RNA in the respect of T2DM.

CTLA-4 rs5742909 polymorphism and cervical cancer risk: A meta-analysis.

Background: Number of studies have been performed to evaluate the relationship between the cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) gene variant rs5742909 polymorphism and cervical cancer risk, but the sample size was small and the results were conflicting. This meta-analysis was conducted to comprehensively evaluate the overall association.

Methods: PubMed, Web of Science, Embase, China Biology Medical Literature database, China National Knowledge Infrastructure, WanFang, and Weipu databases were searched before July 31, 2018.

[The relationship between HalphaD-5 and HbetaD-2 in infertile women's fimbriae tubes with adhesions and atresias].

Objective: To investigate the expression and relationship of human alpha defensin-5 (HalphaD-5) and human beta defensin-2 (HbetaD-2) in human fimbriae tubes with adhesions and atresias.

Methods: The tissue samples were collected from 30 human fimbriae tubes with adhesions and atresias, and 30 cases without adhesions and atresias. The expression of HalphaD-5 and HbetaD-2 in fimbriae tube tissue were measured by immunohistochemical SP methods.

[The expression and significance of TGF-beta 1 and its receptors in infertile women's fimbriae tubes with adhesions and atresias].

Objective: To profile the expression of transforming growth factor-beta1 (TGF-beta1) and its receptors (TGF-beta R1 and TGF-beta R2) in human fimbriae tubes to valuate the role of TGF-beta 1 signal system in adhesions and atresias formation of infertile women's fimbriae tubes.

Methods: The expressions of TGF-beta 1 and its receptors (TGF-beta R1 and TGF-beta R2) in fimbriae tubes were measured by immunohistochemical SP methods in 30 human fimbriae tube with adhesions and 15 cases without adhesions. The average integrated optical density (IOD) value of positive staining was tested by Image pro-plus 6.