Publications by authors named "Shivaramakrishnan Balasubramanian"
Article Synopsis
- Parkinson's disease (PD) is a challenging neurodegenerative disorder with few treatment options, and this study explores repurposing the FDA-approved phosphodiesterase 4 (PDE4) inhibitor roflumilast (ROF) as a potential therapy.
- In experiments with Drosophila models of PD, ROF demonstrated positive effects on movement and antioxidant activity, but its effectiveness was limited by its low distribution in the brain.
- To enhance brain delivery, researchers created nanostructured lipid carriers (NLCs) for ROF, which showed prolonged release, reduced inflammatory markers, and improved behavioral outcomes compared to pure ROF, suggesting NLCs could be a valuable method for delivering treatments for PD
Clinicians and researchers are exploring safer and novel treatment strategies for treating the ever-prevalent Parkinson's disease (PD) across the globe. Several therapeutic strategies are used clinically for PD, including dopamine replacement therapy, DA agonists, MAO-B blockers, COMT blockers, and anticholinergics. Surgical interventions such as pallidotomy, particularly deep brain stimulation (DBS), are also employed.
View Article and Find Full Text PDFEndocannabinoid system has been extensively studied in recent decades, particularly the cannabinoid receptors CB1 and CB2, due to their important role in neuroinflammation. Among these, CB2 has gained prominence due to its selective overexpression in glial cells during neuroinflammation. In contrast to CB1 agonists, CB2 agonists have no side effects such as ataxia, hypothermia, euphoria, psychological, or addiction liabilities.
View Article and Find Full Text PDF5-Aminosalicylic acid (5-ASA) is an aminosalicylate anti-inflammatory drug, which is also known as mesalazine or mesalamine. Currently employed in treating inflammatory bowel disease, ulcerative colitis, inflamed anus or rectum, and maintain remission in Crohn's disease. Evidence from the researchers highlighted its significant re-epithelization in allergic asthma, aphthous, and gastric ulcerative conditions.
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