Publications by authors named "Shivansh Nigam"
Metabolic reprogramming, a key hallmark of cancer, plays a pivotal role in fulfilling the accelerated biological demands of tumor cells. Such metabolic changes trigger the production of several proinflammatory factors, thereby inciting cancer development and its progression. Serine protease inhibitor Kazal Type 1 (SPINK1), well known for its oncogenic role and its upregulation via acute-phase reactions, is highly expressed in multiple cancers including colorectal cancer (CRC).
View Article and Find Full Text PDFCaspase-3 mediated programmed cell death by a gold-stabilised peptide carbene.
Bioorg Med Chem Lett
November 2019
Article Synopsis
- Scientists created new compounds using a special three-part protein (a tripeptide) that has a unique ingredient called thiazolylalanine.
- They made gold and mercury compounds that were studied for their structure and stability using different scientific methods.
- One of the gold compounds was found to help fight breast cancer by causing cancer cells to die, and they could see it getting inside the cells using a special light method.
Purpose: Serine peptidase inhibitor, Kazal type-1 (SPINK1) overexpression defines the second most recurrent and aggressive prostate cancer subtype. However, the underlying molecular mechanism and pathobiology of SPINK1 in prostate cancer remains largely unknown.
Experimental Design: miRNA prediction tools were employed to examine the 3'UTR for miRNA binding.
A simple synthesis route for growth of Ag/AgO nanoparticles (NPs) in large quantitative yields with narrow size distribution from a functional, non-activated, Ni (II) based highly flexible porous coordination polymer (PCP) as a template has been demonstrated. This template is a stable storage media for the NPs larger than the pore diameters of the PCP. From EPR study it was concluded that NPs were synthesized via two mechanisms i.
View Article and Find Full Text PDF