Publications by authors named "Shivani S Shinde"
Article Synopsis
- Dental caries is a widespread, chronic oral infection caused by cariogenic bacteria, with drug resistance complicating treatment efforts.
- A study isolated and identified soil actinomycetes to test their antibacterial and anti-biofilm effects on antibiotic-resistant cariogenic bacteria, specifically Streptococcus mutans, an identified strong biofilm producer.
- The actinomycete isolate MMS-10 exhibited significant inhibitory effects on S. mutans growth and biofilm formation, and was identified as Streptomyces luridiscabiei, with its active compound being 2,4-Di-tert-butylphenol, showing potential as a drug-like agent.
MDS/MPN (myelodysplastic syndrome/myeloproliferative neoplasm) overlap syndromes are myeloid malignancies for which allogeneic hematopoietic stem cell transplant (allo-HSCT) is potentially curative. We describe transplant outcomes of 43 patients - 35 with chronic myelomonocytic leukemia, CMML (of which 17 had blast transformation, BT) and eight with MDS/MPN-unclassifiable (MDS/MPN,U). At median follow-up of 21 months, overall survival (OS), cumulative incidence of relapse (CIR) and non-relapse mortality (NRM) were 55%, 29%, and 25% respectively in CMML without BT and 47%, 40%, and 34% respectively in CMML with BT.
View Article and Find Full Text PDFPurpose: Paclitaxel can cause an acute pain syndrome (P-APS), considered to be an acute form of neuropathy and chronic chemotherapy-induced peripheral neuropathy (CIPN). Anecdotal reports suggested that gabapentin may be helpful in the prevention of these toxicities. The purpose of this pilot study was to obtain data to support or refute the utility of pregabalin for the prevention of P-APS and CIPN.
View Article and Find Full Text PDFBackground: The combination of increased parity and shorter breastfeeding duration might increase the odds of the least differentiated triple-negative breast cancer (BC) phenotype, theoretically because an expanded progenitor cell population from each pregnancy would incompletely differentiate postpartum.
Methods: Subjects consisted of a consecutive case series of 2473 women treated for invasive breast cancer between 2001 and 2006. Breast cancer phenotype (triple-negative BC, vs non-triple-negative BC) was compared with reproductive and demographic information.