Publications by authors named "Shivani Kumaresan"
Article Synopsis
- Excess dietary salt may lead to inflammation and hypertension by altering the gut microbiome and increasing the formation of immune-reactive compounds called IsoLGs in immune cells.
- Research found that high salt intake is linked to specific changes in gut bacteria, particularly increases in Firmicutes, Proteobacteria, and Prevotella, which are associated with higher blood pressure in both humans and mice.
- The study suggests that targeting the gut microbiome could be a new approach to prevent and treat the inflammation and hypertension caused by excessive salt consumption.
Sodium accumulates in the interstitium and promotes inflammation through poorly defined mechanisms. We describe a pathway by which sodium enters dendritic cells (DCs) through amiloride-sensitive channels including the alpha and gamma subunits of the epithelial sodium channel and the sodium hydrogen exchanger 1. This leads to calcium influx via the sodium calcium exchanger, activation of protein kinase C (PKC), phosphorylation of p47, and association of p47 with gp91.
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