Relationship between depressive symptom severity and amygdala volume in a large community-based sample.

Amygdala is an affective processing center that regulates and assigns valence to different emotions and has been implicated in the pathophysiology of mood disorders. This population-based study employed a community sample of 1747 adults to examine relationships between amygdala volume and depressive symptom severity. Neuroimaging data from participants in the Dallas Heart Study were used.

Microtubule associated protein 2 in bipolar depression: Impact of pregnenolone.

Background: Pregnenolone, and related neurosteroids, may have antidepressant properties. Preclinical research proposes that microtubule associated protein 2 (MAP2) binding may be a mechanism for antidepressant properties of pregnenolone. Thus, MAP2 might be a novel target for antidepressant therapy.