A review on cyclin-dependent kinase 5: An emerging drug target for neurodegenerative diseases.

Cyclin-dependent kinase 5 (CDK5) is the serine/threonine-directed kinase mainly found in the brain and plays a significant role in developing the central nervous system. Recent evidence suggests that CDK5 is activated by specific cyclins regulating its expression and activity. P35 and p39 activate CDK5, and their proteolytic degradation produces p25 and p29, which are stable products involved in the hyperphosphorylation of tau protein, a significant hallmark of various neurological diseases.

An Intelligent Sensor Based Decision Support System for Diagnosing Pulmonary Ailment through Standardized Chest X-ray Scans.

Academics and the health community are paying much attention to developing smart remote patient monitoring, sensors, and healthcare technology. For the analysis of medical scans, various studies integrate sophisticated deep learning strategies. A smart monitoring system is needed as a proactive diagnostic solution that may be employed in an epidemiological scenario such as COVID-19.

A Pragmatic Ensemble Strategy for Missing Values Imputation in Health Records.

Pristine and trustworthy data are required for efficient computer modelling for medical decision-making, yet data in medical care is frequently missing. As a result, missing values may occur not just in training data but also in testing data that might contain a single undiagnosed episode or a participant. This study evaluates different imputation and regression procedures identified based on regressor performance and computational expense to fix the issues of missing values in both training and testing datasets.

Missed ulnar nerve injury and closed forearm fracture in a child.

Ulnar nerve injury in closed fracture of forearm in children is uncommon.Commonly, neurapraxia is the reason for this palsy but other severe injuries or nerve entrapment has been reported in some cases. The importance of diagnosis concerning the types of the nerve injury lies in the fact that they have totally different management.

Awareness of genetic testing for colorectal cancer predisposition among specialists in gastroenterology.

Objectives: Adult gastroenterologists practicing in New York State were surveyed to determine their practice with regard to identifying family histories consistent with inherited forms of colorectal cancer, and to assess their awareness of cancer genetic counseling and molecular genetic testing for familial adenomatous polyposis (FAP) and hereditary nonpolyposis colorectal cancer (HNPCC).

Methods: A closed-ended questionnaire was mailed to 815 gastroenterologists identified through the membership Directory of the American Gastroenterological Association (1998). Two mailings resulted in a response rate of 35%.