Publications by authors named "Shivali Berera"
Article Synopsis
- The study explored the link between Crohn's disease activity, fatigue, and neurocognitive function in adults, comparing 25 patients with Crohn's to 26 healthy controls.
- Patients with Crohn's disease reported significantly higher levels of fatigue, particularly when symptomatic, but showed no differences in neurocognitive accuracy or speed compared to healthy individuals.
- However, those with active Crohn's disease had slower response times in social cognition and episodic memory tasks, indicating a relationship between disease activity and cognitive processing, regardless of fatigue levels.
Article Synopsis
- The study tested the combination of pentoxifylline (PTX) and vedolizumab (VDZ) against VDZ alone in adults with Crohn's disease to see if it was safer and more effective over 24 weeks.
- Results showed no significant difference in clinical or endoscopic remission rates between the two groups, but the PTX group had improved clinical responses and reduced tumor necrosis factor (TNF) levels.
- The authors concluded that while the combination treatment didn’t outperform VDZ monotherapy in overall remission, it appeared safe and demonstrated some benefits, suggesting further research should be conducted.
Background & Aims: Guidelines recommend that all colorectal tumors be assessed for mismatch repair deficiency, which could increase identification of patients with Lynch syndrome. This is of particular importance for minority populations, in whom hereditary syndromes are under diagnosed. We compared rates and outcomes of testing all tumor samples (universal testing) collected from a racially and ethnically diverse population for features of Lynch syndrome.
View Article and Find Full Text PDFIntestinal involvement of cryoglobulinemia is an uncommon manifestation and marker of severe vasculitis. We describe the case of a woman admitted to our service for management of acute renal failure and progressive gastrointestinal symptoms after initiating hepatitis C virus treatment with ribavirin and sofosbuvir 4 weeks prior. With an undetectable hepatitis C viral load and persistent symptoms despite hepatitis C virus therapy cessation, an upper endoscopy revealed duodenal sloughing, erythema, and bleeding, sparking suspicion for recurrence of cryoglobulinemic vasculitis.
View Article and Find Full Text PDFBackground & Aims: Microsatellite instability (MSI) in colorectal cancer cells results from deficient mismatch repair (MMR) protein function, either acquired or from germline alterations such as in patients with Lynch syndrome. Universal screening initiatives for Lynch syndrome have been encouraged. However, little is known about the true prevalence of MMR deficiency and MSI in colorectal tumors among individuals from different racial and ethnic subgroups or their clinical effects in these populations.
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