A vitamin C-based natural deep eutectic solvent for the synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives.

Efficient and green protocols were reported to synthesize 2,3-dihydroquinazolin-4(1H)-one derivatives in natural deep eutectic solvent (NADES). NADES was prepared from ascorbic acid (AA) and choline chloride (ChCl) with reduced or null toxicity, biocompatibility, and low cost. The ChCl/AA NADES was successfully used in the synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives via the condensation reaction of aldehydes with 2-aminobenzamide and the three-component reactions of aldehydes, isatoic anhydrides and ammonium salts under solvent-free conditions.

Comparison of outcomes and complications in conventional versus ultrasound-accelerated catheter directed thrombolysis for treatment of pulmonary embolism: A systematic review and meta-analysis.

Background: Acute submassive a massive pulmonary embolism are known as leading causes of cardiovascular morbidity and mortality in emergency departments. Choosing the optimal type of catheter directed thrombolysis (CDT) for treatment of pulmonary embolism presents a quandary to the practitioners. To the best of our knowledge, there is no meta-analysis comparing superiority of conventional CDT and ultrasound-accelerated catheter directed thrombolysis (USACDT).