Molecular signaling directing neural plate border formation.

During embryonic development, the vertebrate embryonic epiblast is divided into two parts including neural and superficial ectoderm. The neural plate border (NPB) is a narrow transitional area which locates between these parts and contains multipotent progenitor cells. Despite its small size, the cellular heterogeneity in this region produces specific differentiated cells.

The Relationship between Body Mass Index, Metal Elements, and Antioxidant Capacity of Semen on The Human Sperm Chromatin.

Background: Sperm chromatin abnormalities are defects in nuclear maturation and DNA integrity. These defects originated from defective spermatogenesis due to a lack of DNA repair during chromatin remodeling. Changes in semen elements can cause damage to chromatin.

The effect of Crocin on sperm parameters disorders induced by peripheral administration of nitrosamines in male rats.

Nitrosamines are carcinogenic agents which can unfavorably affect some male reproductive parameters. Humans are exposed to nitrosamines through various routes, the most important of which is the diet. Crocin is a carotenoid and is accountable for the red color of saffron.

The effect of royal jelly and silver nanoparticles on liver and kidney inflammation.

Objective: Royal jelly (RJ) is a honey bee product for which, anti-inflammatory properties were shown . Nanoparticles, including nano-silver (NS), are plausible inflammation inducers that act by activation of immune cells and consequent production of pro-inflammatory cytokines. This project aimed to explore immunomodulatory effects of royal jelly and nano-silver on the kidney and liver.

Ceratonia siliqua (Carob) extract improved in vitro development of vitrified-warmed mouse germinal vesicle oocytes: assessment of possible mechanism.

Oocyte banking is a vital step for safekeeping and spreading genetic resources of animals. It is also used for fertility preservation of human. Oocyte vitrification is closely related to the lower developmental competence which includes the cryo-injury arisen during vitrification.

Does improve toxic effect of Malathion on male reproductive parameters?

Background: has antioxidant and free-radical-scavenging properties. Malathion is the most common organophosphate, which is capable to produce free radicals and induce disturbance on some of male reproductive parameters. This study was designed to evaluate the effects of extract against damage induced by Malathion to the reproductive parameter of male rats.

Anti-inflammatory, anti-apoptotic, and antioxidant actions of Middle Eastern Phoenix dactylifera extract on mercury-induced hepatotoxicity in vivo.

Mercuric chloride (MC) is a complex substance which is capable to produce free radicals. Middle Eastern Phoenix dactylifera (MEPD) is a flowering plant of palm family with potent antioxidant feature. Due to the increasing use of herbs in medicine, this study was designed to assess the effects of MEPD and MC on inflammatory apoptogenic, oxidative and histomorphometric alterations in liver.

Evaluation of male infertility treatment following Rhus coriaria extract administration on rats exposed to morphine.

Morphine is the most common analgesic drug that is widely used in post-operative interventions. This drug causes free radical accumulation leading to spermatogenesis failure. Antioxidant agents like Sumach (Rhus coriaria) neutralize cellular free radicals.

Attenuates Myleran-induced Reproductive Damage by Decreasing Oxidative Stress and Lipid Peroxidation in Male Rats.

Context: is an herbal with potent antioxidant and it has been shown to have beneficial effects during short-term administration. Myleran (MYL) is used for treatment of certain types of tumors. MYL produces free radicals and induces disturbance in sperm parameters.

Improvement of on Morphine Toxicity in Prefrontal Cortex in Rats.

Background: () is an associate of the umbelliferae family with several therapeutic attributes. Morphine is known as a major risk factor in the development of functional disorder of several organs.

Objective: This study was designed to evaluate the effects of extract against morphine-induced damage to the brain prefrontal cortex (PC) of rats.

extract reduces hepatotoxicity by antioxidative properties following dichlorvos administration in rats.

Ipomoea aquatica (IA) with antioxidant properties is used in therapeutic trends. An organophosphate, dichlorvos (Dich), is a common insecticide with various side effects on living tissues. This study examines the role of IA on Dich-induced hepatotoxicity in male rats.

Retraction Note to: The protective effect of Pentoxifylline on testopathy in male rats following Dimethyl Nitrosamine administration: An experimental study.

[This retracts the article on p. 738 in vol. 17.

The protective effect of Pentoxifylline on testopathy in male rats following Dimethyl Nitrosamine administration: An experimental study.

Background: Nitrosamines as a carcinogenic agent has unfavorable effects on some of the male reproductive parameters. Pentoxifylline (PX) is a xanthine derivative used as a drug inhibiting the inflammatory factors, reducing blood viscosity, improving peripheral blood flow, and so on. The aim of the present study is to evaluate the effects of PX against Dimethyl nitrosamine (DMN)-inducing the damage to the reproductive parameter of male rats.

Resveratrol attenuates malathion-induced liver damage by reducing oxidative stress.

Background: Malathion is an organophosphate insecticide which disrupts the antioxidant system of the body. Resveratrol is a phytoestrogen and antioxidant of the red grape.

Aim And Objective: This study was designed to evaluate the effects of resveratrol against toxic effects of malathion to the liver of rats.

Extract Attenuates Ethanol-induced Renal Damage by Reducing Oxidative Stress and Lipid Peroxidation in Rats.

Background: Alcohol consumption is capable of producing free radicals and inducing disturbance in body antioxidant. () is a vegetable and it has beneficial antioxidant effects.

Materials And Methods: Forty-eight Wistar rats were divided randomly into eight groups ( = 6): control normal (saline) and ethanol (5g EtOH/kg body weight/24h) control groups, groups (50, 100, and 150mg/kg), and + ethanol treated groups (50, 100, and 150mg/kg).

Toxic Effects of Methotrexate on Rat Kidney Recovered by Crocin as a Consequence of Antioxidant Activity and Lipid Peroxidation Prevention.

Background: The application of methotrexate (MTX) as a chemotherapy agent and immune system suppressant has various side effects. Crocin, a xanthine derivative plant, has many therapeutic benefits. This study was planned to assess the effect of crocin on renal toxicity of MTX in a rat model.

Effect of Harmine on Nicotine-Induced Kidney Dysfunction in Male Mice.

Background: The nicotine content of cigarettes plays a key role in the pathogenesis of kidney disease. Harmine is a harmal-derived alkaloid with antioxidant properties. This study was designed to evaluate the effects of harmine against nicotine-induced damage to the kidneys of mice.

Genistein improve nicotine toxicity on male mice pancreas.

Nicotine is the most toxic factor of tobacco. Genistein is a phytoestrogen and antioxidant that has numerous health benefits. The aim of this study is to evaluate the effects of genistein against toxic properties of nicotine to the pancreas of mice.

Can royal jelly protect against renal ischemia/reperfusion injury in rats?

Royal jelly (RJ) is a honeybee secretion, has numerous medicinal properties in particular antioxidant activities. Ischemia/reperfusion (I/R) is one of the main challenges in acute kidney damage. This study was designed to assess the anti-inflammatory and protective effects of RJ against I/R-induced renal disorders.

Effect of Falcaria Vulgaris on Milk Production Parameters in Female Rats' Mammary Glands.

Falcaria Vulgaris (F.Vulgaris) is a multipurpose herb in traditional medicine, containing essential amino acids, vitamins and numerous nutrients. The aim of this study was to determine the effects of F.

Association between the FAS/FASL Variants and Risk of Male Infertility in Asian Populations; A Systematic Review and Meta-Analysis.

: Studies suggest that FAS/FASL polymorphisms are associated with male infertility; however, their results are still inconclusive. Therefore, this systematic review and meta-analysis aimed to summarize and clarify the overall association of FAS/FASL polymorphisms and risk of male infertility. : Our search was conducted on the databases of Science Direct, PubMed and Google Scholar.

Harmine shows therapeutic activity on nicotine-induced liver failure in mice.

This experiment evaluated the effects of harmine against nicotine-induced damage to the liver of mice. Nicotine is a major toxic component of cigarette smoke and a major risk factor for functional disorders in the liver, because it induces oxidative stress. Harmine is a harmal-derived alkaloid with therapeutic and antioxidant properties.