Overexpression of PIN1 in patients with severe COVID-19.

This study aimed to investigate the significant expression of Peptidyl prolyl cis-trans isomerase (PIN1) as a key regulator of COVID-19 cycle. A quantitative real-time polymerase chain reaction (qRT-PCR) measured the expression levels of PIN1 in the serum of mild and severe patients and evaluated its association with clinical parameters. ROC curve analysis was performed to evaluate the expression of PIN1 for the diagnosis of COVID-19 between mild and severe patients.