Publications by authors named "Shiv Rajan"

Solitary fibrous tumors (SFTs) are uncommon mesenchymal tumors that primarily develop in the visceral pleura. The chest wall is an extremely rare site for the origin of these tumors and therefore presents unique challenges for diagnosis and management. We present a rare case of solitary fibrous tumors of the chest wall (SFTCW), necessitating extensive resection and complex reconstruction.

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  • Vulvar carcinoma, primarily squamous cell carcinoma, is a rare form of cancer occurring in the external female genitalia, necessitating a multidisciplinary treatment approach often involving surgery and adjuvant therapy based on stage and other factors.
  • A retrospective study conducted in India over eight years included 21 patients with vulvar cancer, analyzing disease stages, treatment methods, and outcomes, revealing a five-year survival rate of about 71%.
  • The study highlighted the importance of individualized treatment plans and the need for strict protocols and regular follow-ups, especially in low-resource settings, to improve patient outcomes in this rare disease.
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Inguinal skin flap necrosis (SFN) is a significant clinical problem associated with inguinal lymph node dissection (ILND). The aetiology of SFN is multifactorial, and its manifestations vary widely. Thermal damage caused by electrocautery during the elevation of the skin flap may contribute to this problem, which has not been studied previously.

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  • The study compared the AJCC 7th and 8th editions of staging systems for patients with gallbladder cancer (GBC) who underwent surgery with curative intent, focusing on their ability to predict survival outcomes.
  • It analyzed data from 240 patients, finding that both staging systems effectively distinguished survival rates based on disease progression, but TNM-8 exhibited superior prognostic capabilities.
  • Notably, TNM-8 upstaged and down-staged some patients compared to TNM-7, leading to significant differences in survival outcomes, particularly highlighting a better prognostic performance for TNM-8.
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Introduction: Male breast cancer is rare and accounts for less than 1% of all breast cancer cases worldwide.

Methods: This retrospective cohort study included all patients of invasive male breast cancer treated with curative intent by a trimodality approach via a multidisciplinary team at an academic university hospital in India between 2009 and 2023. Records were identified from a prospectively maintained database.

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  • Gallbladder cancer (GBC) is often diagnosed incidentally (IGBC) and offers a chance for early intervention, leading to improved patient outcomes.
  • A study analyzed 125 IGBC patients from a database at a tertiary care center in India, revealing that over half were ineligible for surgery, but almost 70% of those who could undergo surgery had successful outcomes.
  • Factors influencing operability include gallbladder wall thickness and time to treatment, highlighting the importance of early detection and referral for better survival rates.
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Background: Cancer stem cell biomarkers SRY (sex-determining region Y)-box 2 (SOX2) and octamer-binding transcription factor 4 (Oct4) account for radioresistance in cervical squamous cell cancers (CSCCs). Their clinical implications are limited and contradictory.

Methods: In this prospective cohort study, we recruited patients with FIGO IB2-IVA CSCC treated with primary chemoradiotherapy on regular follow-up.

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Standard minimally invasive Ivor Lewis oesophagectomy is performed through a multiport technique using carbon dioxide. However, access to video-assisted thoracoscopic surgery (VATS) is increasingly shifting to a single-port approach due to its proven safety and efficacy in lung surgeries. Therefore, the preamble of this submission is to describe, 'How I do differently' uniportal VATS MIO in three major steps: (a) VATS dissection through a single 4-cm incision in a semi-prone position without artificial capnothorax; (b) fluorescence dye to check conduit perfusion and (c) intrathoracic overlay anastomosis with a linear stapler.

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Leiomyomas are the most common benign tumours of oesophageal smooth muscle origin. In this era of constantly evolving medical technology, video-assisted, robot-assisted and endoscopic approaches are the minimally invasive strategies for the excision of these lesions. Here, we report our modification of this surgery.

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Background: Locoregional recurrence of oral cancer causes significant morbidity. This study aims at assessing the functional outcomes of patients undergoing treatment for recurrent oral squamous cell carcinoma.

Methods: This study was done in a tertiary care center in North India and includes prospective cohort of 179 recurrent oral carcinoma patients, from September 2017 to September 2018.

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Background And Objective: Gallbladder cancer (GBC) is an aggressive malignancy where curative resection is possible in few and survival is poor. There are limited data on outcomes in patients with de novo GBC from endemic regions undergoing surgery for curative intent. We report survival outcomes in this group of patients from a region with high incidence of disease.

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Polymorphous adenocarcinoma (PA) of the salivary glands is a rare malignancy that predominantly affects the minor salivary glands of the palate. Major salivary gland involvement is rare (<5%). The submandibular gland is a highly unusual location for this tumour.

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Backgrounds: Oral squamous cell cancer (SCC) is one of the most common cancers. The most common age of presentation is fifth to sixth decade. Management of this disease is dictated by stage, age, and related comorbidities.

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Background: Coronavirus disease 2019 (COVID-19) has impacted cancer care globally. The aim of this study is to analyze the impact of COVID-19 on cancer healthcare from the perspective of patients with cancer.

Methods: A cross-sectional survey was conducted between June 19, 2020, to August 7, 2020, using a questionnaire designed by patients awaiting cancer surgery.

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Background: The novel coronavirus pandemic (COVID-19) hinders the treatment of non-COVID illnesses like cancer, which may be pronounced in lower-middle-income countries.

Methods: This retrospective cohort study audited the performance of a tertiary care surgical oncology department at an academic hospital in India during the first six months of the pandemic. Difficulties faced by patients, COVID-19-related incidents (preventable cases of hospital transmission), and modifications in practice were recorded.

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The unprecedented novel coronavirus disease pandemic has wreaked havoc on healthcare systems worldwide and raised myriads of questions. The delivery of cancer care is an essential service that cannot take a backseat, even amid a global pandemic. Oncology involves the disciplines of surgical oncology, radiotherapy, chemotherapy, and palliative care which are all affected, including the possible impact of the pandemic on the mental health of patients and healthcare workers alike.

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Backgrounds/aims: Transglutaminase 2 (TG2) is known to be an important mediator of inflammation induced carcinogenesis pathway. Chronic inflammation is the most important causative factor in Gallbladder cancer (GBC) carcinogenesis. We analyzed the expression of TG2 in GBC and its role as potential prognostic marker, first of its kind study.

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