Streamlined Data Processing for Determination of Equilibrium Dissociation Constants with Accurate Constant via Transient Incomplete Separation (ACTIS).

The determination of accurate equilibrium dissociation constants, , of protein-small molecule complexes is important but challenging as all established methods have inherent sources of inaccuracy. Accurate Constant via Transient Incomplete Separation (ACTIS) is a new method for determination using transient incomplete separation of the complex from the unbound small molecule in a pressure-driven flow inside a capillary. ACTIS is accurate, and its accuracy is invariant to variations in geometries of both the fluidic system and the flow.

Changes in body mass index following primary elective total hip arthroplasty. Correlation with outcome at 2 years.

Weight has been shown to increase following total hip arthroplasty (THA). It is also reported that the preoperative weight does not correlate to the outcome of the surgery. Body mass index (BMI) is regarded as a better tool for analysis.