The association of angiographic collaterals with long-term clinical outcomes in patients with chronic stable angina.

Objectives: To determine the impact of coronary collaterals in stable angina.

Background: Whether spontaneously visible coronary collaterals are associated with long-term clinical outcomes in stable angina remains unclear.

Methods: We prospectively enrolled patients with stable angina referred for coronary angiography and followed them clinically for 1 year.

Sulindac derivatives that activate the peroxisome proliferator-activated receptor gamma but lack cyclooxygenase inhibition.

A series of novel derivatives of the nonsteroidal anti-inflammatory drug (NSAID) sulindac sulfide were synthesized as potential agonists of the peroxisome proliferator-activated receptor gamma (PPARgamma). Nonpolar and aromatic substitutions on the benzylidene ring as well as retention of the carboxylic acid side chain were required for optimal activity. Compound 24 was as potent a compound as any other in the series with an EC50 of 0.

Desmethyl derivatives of indomethacin and sulindac as probes for cyclooxygenase-dependent biology.

Cyclooxygenases (COX) have been implicated in the etiology of a number of diseases, but defining the precise contribution of COXs to these diseases is challenging. Potent COX inhibitors exist, but they display off-target effects. 2'-Desmethyl derivatives of indomethacin and sulindac sulfide were synthesized that demonstrated reduced COX inhibitory activity but were inducers of peroxisome proliferator-activated receptor gamma-dependent transcription, adipocyte differentiation, or apoptosis of colon cancer cell lines.