Publications by authors named "Shitian Qin"
Long-term inflammation and impaired angiogenesis are thought to be the causes of delayed healing or nonhealing of diabetic wounds. S100A12 is an essential pro-inflammatory factor involved in inflammatory reactions and serves as a biomarker for various inflammatory diseases. However, whether high level of S100A12 exists in and affects the healing of diabetic wounds, as well as the underlying molecular mechanisms, remain unclear.
View Article and Find Full Text PDFSingle-cell profiling reveals transcriptomic signatures of vascular endothelial cells in non-healing diabetic foot ulcers.
Front Endocrinol (Lausanne)
December 2023
Article Synopsis
- The study investigates diabetic foot ulcers (DFUs), focusing on non-healing wounds and how high glucose levels impair endothelial cell functions, potentially hindering healing.
- By analyzing single-cell RNA sequencing data, researchers identified differences in endothelial cells from healing and non-healing DFUs, showing impaired angiogenesis and immune response.
- The findings reveal crucial transcriptomic changes in non-healing DFUs, offering new angles for targeted treatments and enhancing our understanding of endothelial cell roles in wound healing.
Pressure therapy (PT) is an effective intervention for reducing scarring, but its underlying mechanism remains largely unclear. Here, we demonstrate that human scar-derived myofibroblasts dedifferentiate into normal fibroblasts in response to PT, and we identify how SMYD3/ITGBL1 contributes to the nuclear relay of mechanical signals. In clinical specimens, reductions in SMYD3 and ITGBL1 expression levels are strongly associated with the anti-scarring effects of PT.
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