Neddylation of protein, a new strategy of protein post-translational modification for targeted treatment of central nervous system diseases.

Neddylation, a type of protein post-translational modification that links the ubiquitin-like protein NEDD8 to substrate proteins, can be involved in various significant cellular processes and generate multiple biological effects. Currently, the best-characterized substrates of neddylation are the Cullin protein family, which is the core subunit of the Cullin-RING E3 ubiquitin ligase complex and controls many important biological processes by promoting ubiquitination and subsequent degradation of various key regulatory proteins. The normal or abnormal process of protein neddylation in the central nervous system can lead to a series of occurrences of normal functions and the development of diseases, providing an attractive, reasonable, and effective targeted therapeutic strategy.

Causal relationships between neuropsychiatric disorders and nonalcoholic fatty liver disease: A bidirectional Mendelian randomization study.

Background: Increasing evidences suggest that nonalcoholic fatty liver disease (NAFLD) is associated with neuropsychiatric disorders. Nevertheless, whether there were causal associations between them remained vague. A causal association between neuropsychiatric disorders and NAFLD was investigated in this study.

IAA Synthesis Pathway of WL35 and Its Regulatory Gene Expression Levels in Potato ( L.).

Indole-3-acetic acid (IAA), as an important regulator of potato growth, seriously affects the growth and yield of potato. Although many studies have reported that IAA-producing Bacillus can promote plant growth, little research has been conducted on its synthesis pathway and molecular mechanisms. In this study, an IAA-producing strain WL35 was identified as , and its yield was 48.

Study on the Constitutive Modeling of (2.5 vol%TiB + 2.5 vol%TiC)/TC4 Composites under Hot Compression Conditions.

The hot deformation behavior of titanium matrix composites plays a crucial role in determining the performance of the formed components. Therefore, it is significant to establish an accurate constitutive relationship between material deformation parameters and flow stress. In this study, hot compression experiments were conducted on a (2.

Risk factors of cerebrospinal fluid leakage after neuroendoscopic transsphenoidal pituitary adenoma resection: a systematic review and meta-analysis.

Introduction: Cerebro spinal fluid (CSF) leakage is common and might lead to severe postoperative complications after endoscopic transsphenoidal pituitary adenoma resection. However, the risk factors of postoperative CSF leakage are still controversial. This article presents a systematic review to explore the explicit risk factors of CSF leakage after endoscopic transsphenoidal pituitary adenomere section.

Biological control of potato common scab and growth promotion of potato by Y6.

Potato common scab, caused mainly by , causes surface necrosis and reduces the economic value of potato tubers, but effective chemical control is still lacking. In this study, an attempt was made to control potato common scab by inoculating potatoes with () and to further investigate the mechanism of biological control. The results showed that Y6 could reduce the disease severity of potato common scab from 49.

Deidentifying Narrative Assessments to Facilitate Data Sharing in Medical Education.

Problem: Narrative assessments are commonly incorporated into competency-based medical education programs. However, efforts to share competency-based medical education assessment data among programs to support the evaluation and improvement of assessment systems have been limited in part because of security concerns. Deidentifying assessment data mitigates these concerns, but deidentifying narrative assessments is time-consuming, resource intensive, and error prone.

Developing a dashboard for program evaluation in competency-based training programs: a design-based research project.

Background: Canadian specialist residency training programs are implementing a form of competency-based medical education (CBME) that requires the assessment of entrustable professional activities (EPAs). Dashboards could be used to track the completion of EPAs to support program evaluation.

Methods: Using a design-based research process, we identified program evaluation needs related to CBME assessments and designed a dashboard containing elements (data, analytics, and visualizations) meeting these needs.

A Poisoning Outbreak Caused by - Chongqing Municipality, December 2020.

belongs to the Fabaceae family and is widely distributed in the southern China. It is toxic for the rotenone contained in its roots and seeds, and ingesting its seeds could result in poisoning. In December, 2020, a poisoning from plant seeds occurred in Chongqing Municipality.

Developing a dashboard for faculty development in competency-based training programs: a design-based research project.

Background: Canadian specialist residency training programs are implementing a form of competency-based medical education (CBME) that requires frequent assessments of entrustable professional activities (EPAs). Faculty struggle to provide helpful feedback and assign appropriate entrustment scores. CBME faculty development initiatives rarely incorporate teaching metrics.

A modified method of coracoid transposition for the treatment of complete dislocation of acromioclavicular joint.

Objective: To report a new method of coracoid transposition for the treatment of complete dislocation of acromioclavicular joint and to evaluate its efficacy.

Methods: We modified Dewar's surgical method as follows: (1) Two small incisions, a transversal incision on the acromioclavicular joint and a longitudinal incision on the coracoid, were made instead of a conventional large arc incision from the acromion to coracoid. (2) The foreign body in the acromioclavicular joint was cleared out.