Publications by authors named "Shirou Kuwabara"

Article Synopsis
  • The study investigates the importance of reinforcing the duodenal stump to prevent leakage after radical gastrectomy in gastric cancer patients, as the effectiveness of different reinforcement methods was not well understood.
  • Conducted across 57 medical centers in Japan, the research analyzed data from over 16,000 patients from 2012 to 2021 and found that 0.93% experienced duodenal stump leakage, with lower incidence rates linked to reinforcement methods like seromuscular sutures and reinforced staplers.
  • Results highlighted that duodenal stump reinforcement is crucial, as leakage rates were lower in higher-volume hospitals and specific patient demographics were identified as risk factors for leakage-related mortality.
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Background: Gastric cancer is the fifth most prevalent malignancy globally and the fourth major contributor to cancer-related mortality. The comparative effectiveness of robotic gastrectomy (RG) versus laparoscopic gastrectomy (LG) at different stages of gastric cancer is unclear regarding surgical and survival outcomes. We compared surgical and survival outcomes between RG and LG in early-stage (cStage I) and advanced (cStage II/III) gastric cancers to elucidate the difference in the efficacy of RG across various stages of gastric cancer.

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Background: Initial chemotherapy (Initial-C) followed by surgery is a promising treatment strategy for peritoneal lavage cytology-positive gastric cancer (CY1 GC) with no other noncurative factors. The aim of this study was to investigate the survival advantage of Initial-C compared to initial surgery (Initial-S) for this disease according to the macroscopic type, which was associated with prognosis and the efficacy of chemotherapy in GC.

Methods: One hundred eighty-nine patients who were diagnosed with CY1 GC with no other noncurative factors at four institutions from January 2007 to December 2018 were enrolled.

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We aimed to clarify the operative feasibility and oncological efficacy of a laparoscopic gastrectomy (LG) for pT4a gastric cancer through comparison with open gastrectomy (OG). We compared surgical and oncological outcomes in 178 patients with pT4a gastric cancer who underwent LG or OG between 2002 and 2016; the background was adjusted using propensity score matching. After score matching, 45 patients were included in each group.

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Article Synopsis
  • - A 60-year-old woman with a background of endometrial cancer and a family history of colorectal cancers presented with bloody stools, leading to the discovery of descending colon cancer and left renal pelvic cancer through colonoscopy and CT scans.
  • - She underwent surgery for both cancers, and the pathological diagnosis indicated advanced colon cancer (Stage IVc) and early-stage renal cancer (Stage I), raising suspicion for Lynch syndrome due to her family history.
  • - Post-surgery, she received chemotherapy and remained free of cancer recurrence nine months later, highlighting the connection between her dual cancers and potential genetic factors related to Lynch syndrome.
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Purpose: Thoracoscopic esophagectomy (TE) is widely used for esophageal cancer treatment. However, the short- and long-term outcomes of TE in older patients remain unknown. Thus, we investigated those outcomes as well as the effectivity of TE in this patient cohort.

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Background: Recent improvements in systemic chemotherapy have provided an opportunity for patients with stage IV gastric cancer (GC) to undergo conversion surgery (CS). The aim of this study was to evaluate the long-term outcomes of patients who underwent CS and to elucidate the prognostic factors for CS in stage IV GC.

Methods: A total of 79 patients who underwent CS with the aim of R0 resection for stage IV GC at six institutions from January 2008 to July 2019 were enrolled.

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Background: Although rare, several immune-related adverse effects can be life-threatening. Here, we describe a metastatic gastric cancer patient presenting with nivolumab-related myasthenia gravis and myocarditis, a previously unreported adverse effect of gastric cancer treatment.

Case Presentation: A 66-year-old man with metastatic gastric cancer visited the emergency department because of dizziness after the first dose of nivolumab.

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Purpose: Previous studies have reported that sarcopenia increases the risk of postoperative complications following colorectal resection. This retrospective study assessed the postoperative complications of rectal resection associated with sarcopenia.

Methods: We retrospectively analyzed 262 patients who underwent curative low anterior resection for primary rectal cancer from January 2008 to May 2020 at our institution.

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When colonic graft is used as an esophageal substitute after esophagectomy, one or two feeding vessels of the colon are cut to obtain sufficient length, the graft is passed via the subcutaneous route, and microvascular anastomosis is often used to avoid fatal complications. Sixteen consecutive ileo-right colonic reconstructions via the posterior mediastinal or retrosternal route with preservation of all four colonic vessels were performed in the past eight years. We presented the surgical technique and evaluation of this surgical method.

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Background: Surgical smoke during operation is a well-known health hazard for medical staff. This study aimed to investigate the dynamics of surgical smoke during open surgery or laparoscopic surgery for colorectal disease.

Methods: This study quantitated particulate matter (PM) counts as part of surgical smoke in 31 consecutive patients who underwent colectomy at the Niigata City General Hospital using a laser particle counter.

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Article Synopsis
  • Asian populations mostly experience right-sided colonic diverticular disease, while Western populations have left-sided issues.
  • The study analyzed 43 patients who underwent surgery for right-sided diverticular bleeding from 2010 to 2019, comparing outcomes between open and laparoscopic surgeries.
  • Laparoscopic surgery resulted in longer operational times but had lower blood transfusion rates and allowed patients to resume meals sooner than open surgery, with no major complications or rebleeding observed in either group.
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Objectives: Incisional hernia is a common problem after colorectal surgery, and a laparoscopic approach does not reduce the incisional hernia rate. Previous reports have described the risk factors for incisional hernia; however, the impact of suture materials remains unclear. As such, this study compared the incisional hernia rate using different suture materials for abdominal wall closure after laparoscopic colorectal cancer surgery.

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Introduction: Gastrointestinal stromal tumor of the stomach with lymph node metastasis is a rare condition, and few cases have been treated by gastrectomy and systematic lymph node dissection.

Presentation Of Case: We report the case of a patient who was treated by local resection with laparoscopic and endoscopic cooperative surgery and lymph node pick-up resection. A 73-year-old woman presented with gastric submucosal tumor and swollen lymph node.

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Article Synopsis
  • - A 63-year-old man experienced complications after undergoing surgery for rectal cancer, including pain in his right thigh, nausea, vomiting, and abdominal pain 17 days post-op.
  • - A CT scan showed that a small loop of bowel had migrated into an unusual space beneath the right obturator nerve, leading to an emergency laparoscopic surgery.
  • - During the surgery, the herniated bowel was fixed, and the obturator nerve was carefully separated and preserved, with a smooth recovery afterward and the patient's thigh pain resolving.
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Article Synopsis
  • The study aimed to compare the effectiveness of two treatment options for gastric outlet obstruction (GOO) caused by gastric cancer: endoscopic stenting and surgical gastrojejunostomy.
  • Data was collected from 179 patients across 42 hospitals, showing that patients who received stents had fewer postoperative complications, but the survival times were similar for both treatment groups.
  • Overall, endoscopic stenting appears to be a viable option, resulting in less morbidity while maintaining similar food intake and survival times compared to gastrojejunostomy.
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Purpose: We report a case in which pigmented peritoneal deposits were found during laparoscopic surgery following preoperative endoscopic tattooing for sigmoid colon cancer.

Methods: The patient's clinical, endoscopic, and histological data from the Niigata City General Hospital were reviewed, as well as the literature on laparoscopic surgery involving the preoperative endoscopic tattoo, with a focus on the relevance of peritoneal deposits and tattooing ink.

Results: A 71-year-old man presented to our hospital complaining of vomiting and abdominal distention.

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Introduction: Non-occlusive mesenteric ischemia (NOMI) is a type of acute intestinal ischemia, and its associated mortality is very high. In laparotomy of NOMI, we often have difficulty determining the area of bowel resection. We herein describe a case in which we detected the area of bowel resection using indocyanine green (ICG) fluorescence imaging.

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Purpose: The aim of this study was to clarify the differences between thoracoscopic esophagectomy in the left decubitus position (LP) and in the prone position (PP) in terms of short-term perioperative outcomes and long-term oncological outcomes after more than 5 years of follow-up.

Methods: Patients with esophageal cancer who underwent thoracoscopic esophagectomy and were followed up for more than 5 years were analyzed retrospectively. Of 142 patients, 72 underwent LP esophagectomy and 70 underwent PP esophagectomy.

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Article Synopsis
  • The study assessed a new continuous incision technique for laparoscopic transcystic choledocholithotomy (LTCL) in 103 patients, achieving a 93% success rate.
  • Success rates for removing bile duct stones varied with size, with a significant drop for stones larger than 20 mm.
  • The technique was found to be safe, with no major differences in complication rates between patients with smaller and larger stones.
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Background: Many cases of choledocholiths formed around sutures and clips used during cholecystectomy have been reported. We describe a case of gallstone formation around a nylon suture after non-biliary surgery. To the best of our knowledge, this is the first report of such a case.

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Objectives: Frequency of CVAPD-related complications in colorectal cancer patients is investigated to clarify the relationship to the clinical factors.

Methods: The subjects were 57 patients with unresectable or recurrent colorectal cancer who received interposition operation of CVAPD during the period from February 2006 to April 2009. The clinical factors including the insertion sites, the indwelling period of time, surgical operators, and the types of CVAPD products were analyzed in relation to the complications.

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Purpose: To test the usefulness of diagnostic peritoneal lavage (DPL) for identifying blunt hollow visceral injury with two different sets of criteria or a combination of the two.

Methods: Fifty victims with physical examinations and/or computed tomography findings equivocal for blunt hollow visceral injury underwent DPL. Whether or not to perform surgery was determined based on Otomo's DPL criteria [lavage white blood cell counts (L-WBC) over lavage red blood cell counts (L-RBC) divided by 150 (L-WBC > or = L-RBC/150) in the presence of hemoperitoneum, or L-WBC over 500/mm(3) (L-WBC > or = 500) in the absence of hemoperitoneum].

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