Publications by authors named "Shirota K"

Article Synopsis
  • Current guidelines advocate for primary PCI in patients experiencing acute myocardial infarction, but there is limited data on its effectiveness in patients over 90 years old.
  • A study in Shimane Prefecture categorized patients with acute coronary syndrome into age groups and found that the use of primary PCI decreases as age increases, with a notable rise in in-hospital mortality for super-old patients compared to old patients.
  • Despite higher in-hospital mortality rates in super-old patients, there was no significant difference in long-term major adverse cardiovascular events when comparing super-old and old patients after 30 days.
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Serous tubal intraepithelial carcinoma, serous tubal intraepithelial lesions (STILs), and the p53 signature are considered to be related to precursor lesions of high-grade serous carcinomas (HGSCs). However, the clinical significance and prognostic implications of these lesion types are currently unknown. We diagnosed three patients with STILs according to the morphological evaluation criteria and combined this with p53 and Ki-67 immunostaining.

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  • There is limited data on the outcomes of patients with diabetes who undergo IVUS-guided PCI, particularly in cases of multivessel disease.
  • The study enrolled 1,021 patients, comparing those with diabetes (560 patients) to those without (461 patients), focusing on the incidence of serious health events after the procedure.
  • Results showed similar one-year clinical outcomes for both groups, indicating that diabetes did not significantly increase risks after the procedure when managed with modern practices.
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Background: Transcatheter aortic valve implantation (TAVI) has recently become more common as a treatment for severe, symptomatic aortic stenosis (AS). Cognitive impairment (CI) is strongly associated with the prognosis of TAVI patients. However, some cognitive assessments currently in use are difficult to perform routinely in the clinical setting.

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  • The study examines the response of a specific subphase in a binary liquid crystal mixture when subjected to an electric field, utilizing specially aligned cells.
  • In the antiferroelectric phases, distortions in the structure induce polarization that aligns with the electric field, but in the 1/2 subphase, the structure initially resists deformation, leading to a significant change in optical properties at low electric field strengths.
  • The findings suggest that thermal fluctuations are crucial in facilitating a reorientation of the liquid crystal structure, contributing to a unique switching behavior seen in certain liquid crystal displays.
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A 10-year-old female rabbit developed an unencapsulated and asymmetrical superficial dermal mass on the neck. The tumour was invasive with central ulceration and contained three different histological components, namely trichoblastomatous, basal cell carcinoma (BCC)-like and undifferentiated carcinomatous. In the trichoblastomatous component, which occupied most of the tumour, epithelial neoplastic cells formed ribbon-like cellular trabeculae with a palisaded appearance and stromal giant cells.

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The aim of this study was to investigate whether a nutritional intervention motivating increased vegetable consumption would be an effective treatment and diet therapy for patients with non-alcoholic fatty liver disease. We examined 15 patients with this disease (5 men and 10 women). During the 6-month intervention period, all participants received a small amount of vegetables twice a month as a nutritional education tool aimed at increasing vegetable consumption.

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Traumatic cardiac rupture is mostly accompanied by tamponade and/or hemopericardium. We experienced a rare case of traumatic right atrial rupture with left hemothorax, but without hemopericardium. A 36-year-old male had a traffic accident, and was transported to our hospital.

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Background: Anterior chest wall arteriovenous graft (ACWAVG) is one option for haemodialysis patients when vessels of the upper extremities become exhausted. We report here the long-term outcomes of ACWAVG with polyurethane.

Methods: From April 2005 to October 2015, nine ACWAVGs with polyurethane grafts were created.

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A new cyclopropanation reaction of allyl phosphates with lithium phosphides has been developed to give cyclopropylphosphines through the formation of both a C-P bond and a cyclopropane ring at the same time, and high selectivity toward cyclopropanation over allylic substitution has been realized by conducting the reaction in the presence of HMPA.

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Article Synopsis
  • A 61-year-old man with congestive heart failure due to severe aortic regurgitation was initially misdiagnosed with concealed infective endocarditis, despite lacking typical symptoms like fever and positive blood cultures.
  • After aortic valve replacement and further examination, Behçet's disease was considered a more likely cause for his symptoms, owing to its association with valvulitis and aortic issues.
  • The case highlights the importance of recognizing Behçet's disease as a potential diagnosis in patients with cardiac involvement, even in the absence of common clinical signs, which could lead to improved treatment and outcomes.
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Papillomaviruses (PVs) usually cause benign proliferative lesions in the stratified epithelium of various animal species. However, some high-risk types of PVs have been proven to lead to malignant transformations. In dogs, several canine papillomaviruses (CPVs) have been identified in malignant lesions and are suggested as one of the risk factors for the development of squamous cell carcinomas (SCCs).

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The fruit of Katsura-uri (Japan's heirloom pickling melon, Cucumis melo var. conomon) possesses a fruity aroma and moderate sweetness. The fruit juice has potential to minimize human postprandial blood glucose levels.

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Previously we purified and characterized a sarcoplasmic serine proteinase (SSP) from the belly muscle of the threadfin bream as a modori-inducing proteinase. In our attempt to clarify the structure and physiological functions of SSP, we successfully cloned the full-length cDNA of SSP (ORF 726 bp). The deduced amino acid sequence of SSP (241 residues) was highly homologous to fish trypsinogen.

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Cases of poor egg production were investigated in 2 layer farms from Ibaraki Prefecture in eastern Japan. To identify any microbial agents that may have caused the problem, necropsy, bacterial isolation, histopathology, and virus detection were performed. Members of the avian adenoviruses was detected by PCR in oviduct samples from both farms; chicken anemia virus coinfection was also confirmed in one of the farms.

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Rodents serve as amplifiers of infections in poultry flocks and can serve as a source of contamination in the environment even after thorough cleaning and disinfection. This study aims to determine the dynamics of occurrence in rodents and its relation to contamination in the layer farm environment, including air dusts and eggs. From 2008 to 2017, roof rats (), environmental swabs, air dusts, and eggs were collected from an intensive commercial layer farm in East Japan and were tested for spp.

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Three strains of chicken anemia virus (CAV) were detected in 11 to 14-weeks old chickens, showing depression, wasting, and increased mortality, from three farms in eastern Japan. Another strain was detected in 12-weeks old chickens from one farm without clinical signs. Bacterial infections were suggested in three farms with clinical signs and its involvement in the occurrence of the diseases might be suspected.

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Article Synopsis
  • Many patients suffering from out-of-hospital cardiac arrest (OHCA) face challenges with neurological recovery post-return of spontaneous circulation (ROSC).
  • The study investigates the role of serum adjusted calcium levels in predicting neurological outcomes after ROSC, suggesting that lower levels may indicate poorer recovery.
  • Data from 190 patients were analyzed, and findings revealed a significant correlation between lower serum adjusted calcium within 48 hours after ROSC and worse neurological outcomes at discharge.
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With the exception to serotype Typhimurium and Enteritidis (serogroups B [O:4] and D [O:9], respectively), there have been very few studies conducted on the respiratory tract as route of infection in chickens with salmonellas from serogroup C1 (O:6,7) Therefore, the purpose of this present study was to determine the potential organ invasion by serotype Potsdam (SP), Mbandaka (SM), and Infantis (SI) from serogroup C1 (O:6,7) and compare their characteristics with those of Enteritidis (SE) on intratracheally (IT) challenged 3-week-old layer chicks. A total of 360 one-day-old White Leghorn layer chicks were acquired from a commercial hatchery and randomly assigned into four treatment groups (SP, SM, SI, and SE, respectively), consisting of three independent trials. Chicks were grown up to 21 days (3 weeks) and IT-challenged thereafter with 10 CFU of respective salmonella organisms per group ( = 30).

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Background: Sarcoidosis is a granulomatous disease histologically characterized by naked granulomas in various mammals. Canine sarcoidosis is a rare disease which can cause nonpruritic papule, plaques and nodules on the trunk, neck, face and ear; it is usually treated with corticosteroids. To date, there are no published reports on alternatives to corticosteroids treatment.

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Malignant Leydig cell tumor (MLCT) is a rare testicular tumor in dogs. We report herein 2 dogs with MLCT and cutaneous metastasis. Grossly, marked enlargement and distortion of the involved testes were noted; on cut surface, the parenchyma was completely replaced by neoplastic tissue.

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A sarcoplasmic serine proteinase (SSP) was purified from threadfin bream (Nemipterus virgatus) belly muscle by ammonium sulfate precipitation and a series of chromatographies including Q-Sepharose, Phenyl Sepharose and Superdex 200. The SSP was purified 1967 folds with a yield of 4.8%.

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