Publications by authors named "Shirokova T"

We studied morphological characteristics of platelets and parameters of platelet aggregation in patients with dilation cardiomyopathy. Augmented aggregatory activity of platelets was found in 76% of patients. In blood of majority of patients we found circulating leukocyte-platelet aggregates.

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A dependence of a health status on a condition of adaptation and of functional reserves of child's organism was studied. It was shown that the health status of contemporary schoolchildren is characterized, alongside with a higher prevalence of poly-organs' and morphological-and-functional deviations and chronic pathologies, by impaired rates and a lack of harmonic physical development as well as by a low level of reserve organism abilities. A variety of measures is suggested to promote the existing system of physical education.

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Using complement fixation test (CFT) in cold, the authors measured the circulating tissue antigens of the brain and liver in 50 subjects (22 patients with hepatocerebral dystrophy, 18 with multiple sclerosis and 10 healthy subjects). The total circulating levels of liver and brain antigens were found to be dependent on the activity and progression of the pathological process in these organs. The CFT may be recommended as an additional test for diagnosing the destructive process in the brain and liver of patients with hepatocerebral dystrophy and multiple sclerosis and for assessing the efficacy of the conducted treatment.

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The changes in the ultrastructure of myelinic fibers of branchial plexus muscular branches have been studied during exposure to acupuncture of different duration. The studies were performed using muscular branches obtained from the forelegs of sexually mature white rats, weighing 150-170 g. The nerves were processed for electron microscopy according to a conventional technique.

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The indices of collagen metabolism (free, peptide- and protein bound hydroxyproline) as well as blood plasma proteolytic activity were studied in repeated immobilization (up to 5 days) and skin electropuncture (up to 8 days) in rats. Repeated immobilization (strong stress) steadily increased the contents of free oxyproline and induced undulating changes in the level of other indices under study. Electropuncture (slight stress) produced a short-term increase in free oxyproline blood plasma level.

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Electron-microscopic examination of the nervous apparatus of the acupuncture points of the rabbit ear has shown that the motor receptor structure of reflexotherapeutic impacts seems to be bundles of nerve fibers with their microenvironment--blood vessels, mast cells, histiocytes. Acupuncture with electrical stimulation and acupuncture based on direct mechanical impact (trauma, compression) and the resultant local inflammation irritate the nerve conductors and initiate the effects of reflexotherapy.

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By means of histochemical method, for revealing cholinergic nervous structures, and electron microscopy, innervation of biologically active points (BAP) and that of neutral areas of the rabbit ear skin has been studied, normal and after acu-, electro- and electroacupuncture. The BAP have more intensive vascularization and innervation, their specific feature is presence of well pronounced nervous fasciculi. The latter are formed by 6-10 fibers 1-6 mcm in diameter.

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When the monolayers of trypsin are compressed on the surface of the medicinal substances solution they remain mixed even when high pressure is applied. The experiments on reversibility also indicate that certain medicinal substances remain in the monolayers. An increase in the surface pressure causes partial (dimedrol, barbamyl) or complete (analgin, amidopyrin) displacement of medicinal substances out of the trypsin monolayer.

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