[Modern strategies for the management of patients who have suffered ischemic stroke or transient ischemic attack].

Modern strategies for secondary prevention of ischemic stroke (IS) are based on long-term use of drugs from three main pharmaceutical groups (antihypertensive, lipid-lowering and antithrombotic drugs). In practical terms, the most difficult thing for a practitioner is the choice of antithrombotic therapy with anticoagulants or antiplatelet agents. Antithrombotic therapy for patients with acute cerebrovascular accidents has changed significantly in recent years.

First CLAS12 Measurement of Deeply Virtual Compton Scattering Beam-Spin Asymmetries in the Extended Valence Region.

Deeply virtual Compton scattering (DVCS) allows one to probe generalized parton distributions describing the 3D structure of the nucleon. We report the first measurement of the DVCS beam-spin asymmetry using the CLAS12 spectrometer with a 10.2 and 10.

First Measurement of Λ Electroproduction off Nuclei in the Current and Target Fragmentation Regions.

We report results of Λ hyperon production in semi-inclusive deep-inelastic scattering off deuterium, carbon, iron, and lead targets obtained with the CLAS detector and the Continuous Electron Beam Accelerator Facility 5.014 GeV electron beam. These results represent the first measurements of the Λ multiplicity ratio and transverse momentum broadening as a function of the energy fraction (z) in the current and target fragmentation regions.

Observation of Correlations between Spin and Transverse Momenta in Back-to-Back Dihadron Production at CLAS12.

We report the first measurements of deep inelastic scattering spin-dependent azimuthal asymmetries in back-to-back dihadron electroproduction in the deep inelastic scattering process. In this reaction, two hadrons are produced in opposite hemispheres along the z axis in the virtual photon-target nucleon center-of-mass frame, with the first hadron produced in the current-fragmentation region and the second in the target-fragmentation region. The data were taken with longitudinally polarized electron beams of 10.

Observation of Azimuth-Dependent Suppression of Hadron Pairs in Electron Scattering off Nuclei.

We present the first measurement of dihadron angular correlations in electron-nucleus scattering. The data were taken with the CLAS detector and a 5.0 GeV electron beam incident on deuterium, carbon, iron, and lead targets.

First Measurement of Timelike Compton Scattering.

We present the first measurement of the timelike Compton scattering process, γp→p^{'}γ^{*}(γ^{*}→e^{+}e^{-}), obtained with the CLAS12 detector at Jefferson Lab. The photon beam polarization and the decay lepton angular asymmetries are reported in the range of timelike photon virtualities 2.25 View Article and Find Full Text PDF

[A Case of Successful Thrombolysis on the Verge of a Reperfusion Revolution in Coronary Cardiology and Vascular Neurology].

Thrombolytic therapy (TLT), as a method of treatment, began to develop in the second half of the 50s of the last century. At that time, there was an accumulation of data on its effectiveness, side effects and contraindications, as well as the development of fibrinolytic drugs, such as fibrinolysin, streptokinase, urokinase, and the conditions for their administration. Official recognition of TLT in regulatory documents began only in the 80s after the development of more effective and safe tissue plasminogen activators.

[REGRESSION OF ATHEROSCLECROTIC LESIONS: MEDICAMENTAL AND ALIMENTARY FACTORS].

The article reports results of clinical studies aimed to elucidate the influence of medicines on the size and density of atherosclerotic plaques in the walls of coronary and cerebral arteries. The phenomenon of regression of atherosclerotic lesions in the survivors of Leningrad siege during a long period of starvation is analyzed. The influence of inhibitors of angiotensin-converting enzyme on apoptosis of smooth muscle and foam cells of atherosclerotic plaques in the sanological mechanisms of atherosclerosis is discussed.

[Ideology of the modern system of stroke prevention].

Modern views of stroke prevention are discussed. Novel and traditional concepts of pathogenesis of acute disorders of cerebral circulation are summarized for the first time, methods for individual prognostication of vascular events are proposed. Universally recognized strategies of stroke prophylaxis are analysed and new approaches to differential preventive treatment depending on the probability of development of pathogenetic variants of cerebral circulation disturbances are proposed.

[Cardiogenic ischemic stroke].

The place of cardiogenic ischemic stroke in the structure of acute cerebral circulation disorders is discussed with reference to modern methods of prognostication, diagnostics, treatment and clinical features of cardiogenic strokes.

[Clinico-instrumental characteristics of arterial hypertension, liable to the ishemic stroke].

Clinico-instrumental characteristics of arterial hypertension, liable to the ishemic stroke were studied. The pecularities of clinical, neurological picture of disease and results of instrumental methods of examination were determined. These peculiarities let to educe the course of arterial hypertension, liable to the ishemic stroke.

[Organizational principles in prophylaxis of stroke].

Modern system of insult prophylaxis intends development of 2 directions: population strategy and individual tactics. The effectiveness of population strategy depends on quality of health survey and of sanitarian-educational work. The effectiveness of individual tactics depends on intensity of clinical, laboratorial and instrumental checkup and elaborating an adequate correction of representative syndromes.

[On the issue of the diagnosis "boundary arterial hypertension"].

Many-year observation of patients with arterial hypertension revealed that late diagnosis of the initial stage of the disease was typical. Time elapsed from the first medical record of an arterial pressure (AP) of higher than 140/90 mmHg to the moment the diagnosis of arterial hypertension was made was 4.5 +/- 1.

[The change of the degree of arterial hypertension after ischemic cerebral stroke according to 24-hour arterial pressure monitoring results].

The paper presents a retrospective analysis of the medical records of 147 patients with arterial hypertension (AH) and old ischemic cerebral stroke (ICS), who had undergone annual hospital treatment and 24-hour arterial pressure monitoring (24HAPM) for five years before ICS developed. The patients were observed and underwent 24HAPM during five years after ICS as well. The changes in average 24-hour systolic arterial pressure (SAP av.

[The clinical features of arterial hypertension complicated by an old ischemic cerebral stroke].

The course of arterial hypertension (AH) was evaluated retrospectively in 306 patients, who had undergone annual hospital examination and treatment during the previous five years. After five years, AH had got complicated with ischemic cerebral stroke (ICS) in 147 patients (group 1). AH had not got complicated with ICS in 149 patients (group 2).

[Some features of coronary artery disease combined with vertebrogenic thoracoalgias].

The subjects of the study were 4223 patients who were examined for heartache between 1998 and 2005. The patients were divided into three groups. Group I were 617 patients with isolated vertebrogenous cardiomyalgia; group II included 1238 patients with coronary heart disease; group III consisted of 2368 who suffered from both conditions.

[Neurological syndromes associated with homocystein dismetabolism].

The article summarizes the results of clinical, neurological, and laboratory examination of patients with hyperhomocysteinemia. The data obtained suggest the existence of common pathobiochemical mechanisms of homocystein, cholesterol, and myelin dysmetabolism. The authors demonstrate that neurological manifestations of hyperhomocysteinemia are associated with the processes of demyelinization in the central and peripheral nervous systems.

[The peculiarities of serum levels of S100b protein and antibodies to it in patients with crisis and stable essential hypertension].

The article covers the results of research into the levels of S100b protein and antibodies to it in the serum of patients with crisis and stable essential hypertension. The results show that neutrophic protein dysmetabolism plays an important role in the pathogenesis of hypertonic dyscirculatory encephalopathy and the forming of cognitive disorder syndrome. The data obtained suggest that hypertensive crises lead to pathologic changes in hematoencephalic barrier permeability and the development of autoimmune reactions with participation of neutrophic proteins.

[Treatment of arterial hypertension after ischemic cerebral stroke].

Lethality associated with secondary cerebral stroke is higher than in primary one. Data on the clinical course of arterial hypertension after stroke are contradictory. In recent years, the risk of a repeated ischemic stroke has been considered to be in a direct correlation with both systolic and diastolic blood pressure (BP), while the optimal BP level differs depending on the type of the stroke.

[Protein HLDF and antibodies to it as molecular pathogenetic factors and new markers of acute cerebral blood circulation disturbances].

Clinic-experimental complex investigation and ELISA determination of protein HLDF as also primary antibodies (Abs) to HLDF values in blood and cerebro-spinal fluid (CSF) of patients with hypertensive crises and acute aterotrombotic ischemic stroke were performed. Statistically improved difference in serum HLDF and Abs content in examined patients in comparison with age-matched controls as also significant intergroup's differences in protein and Abs dynamic content were determined. Correlation between content and dynamics of investigated factors in CSF and blood serum with determined clinical and instrumental parameters was revealed.