Publications by authors named "Shirlie Roy Chowdhury"
Article Synopsis
- New variants of SARS-CoV-2 highlight the need for effective treatments, leading to the discovery of a powerful monoclonal antibody called P4A2 that neutralizes all current variants, including Omicron.!
- The structure of the P4A2 antibody reveals that its target on the virus's spike protein remains unchanged across different variants, ensuring its effectiveness against circulating strains.!
- Testing in mice shows that administering P4A2 can protect against infections from these variants, suggesting significant therapeutic potential for future SARS-CoV-2 variants as well.!
Commercial dengue virus (DENV) nonstructural-1 (NS1) Ag detection immunoassays often perform poorly, particularly in secondary DENV infection. To develop a highly sensitive NS1 ELISA, we generated a large repertoire of anti-DENV NS1 mouse mAbs (n = 95) that falls into 36 mAb classes based on binding specificities. The identified mAb pair, capable of efficiently detecting NS1 from four DENV serotypes in an immunoassay, was selected based on multiparametric analysis.
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