Impaired Pentose Phosphate Pathway in the Spinal Cord of the hSOD1 Mouse Model of Amyotrophic Lateral Sclerosis.

Impairments in energy metabolism in amyotrophic lateral sclerosis (ALS) have long been known. However, the changes in the energy-producing pathways in ALS are not comprehensively understood. To investigate specific alterations in glucose metabolism in glycolytic, pentose phosphate, and TCA cycle pathways, we injected uniformly labeled [U-C]glucose to wild-type and hSOD1 mice at symptom onset (80 days).