Publications by authors named "Shirley Quintana"

Article Synopsis
  • The combination of all-trans retinoic acid and anthracyclines has greatly improved acute promyelocytic leukemia (APL) treatment outcomes, particularly in areas without access to arsenic trioxide.
  • Despite these advances, low- and middle-income countries (LMIC) still struggle with high mortality rates during treatment due to inadequate management of complications.
  • A study involving 806 APL patients across several South American countries showed a reduction in induction mortality to 14.6% and an 81% overall survival rate over four years, demonstrating the benefits of international clinical collaboration.
View Article and Find Full Text PDF

Purpose: Major progress has occurred in multiple myeloma (MM) treatment in recent years, but this is not seen in low- and middle-income countries.

Materials And Methods: We retrospectively assessed the efficacy and safety of cyclophosphamide, thalidomide, and dexamethasone (cyclophosphamide 400 mg/m for 5 days, thalidomide 100 mg once daily, if tolerated, and dexamethasone 40 mg once weekly; in 28-day cycles) in patients with newly diagnosed MM treated at our institution between April 2008 and December 2012. Survival outcomes were estimated by the Kaplan-Meier method.

View Article and Find Full Text PDF

Background: Natural killer/T-cell lymphoma (NKTCL), part of T-cell and NK-cell neoplasms in the World Health Organisation (WHO) classification, is an aggressive lymphoma with poor prognosis more predominantly seen in Asian and South American countries. This study evaluates the factors associated with survival among patients with newly diagnosed NKTCL in Peru.

Methods: Information was abstracted from medical records (MR) for all NKTCL patients >13 years of age at the Instituto Nacional de Enfermedades Neoplasicas (INEN) between 2002 and 2011.

View Article and Find Full Text PDF

Introduction: Adjuvant chemo radiotherapy is the standard treatment in Western countries in gastric cancer patients submitted to curative resection. INT0116 pivotal trial established adjuvant chemo radiation as the standard care for resected high risk adenocarcinoma of the stomach in US however was hampered by suboptimal surgery. There is controversial data about efficacy of this adjuvant therapy in patients who have undergone D2 lymphadenectomy predominantly.

View Article and Find Full Text PDF