Publications by authors named "Shirley Guzman"
Background: It has been suggested that the adipokine resistin links obesity and insulin resistance, although how resistin acts on muscle metabolism is controversial. We aimed to quantitatively analyse the effects of resistin on the glucose metabolic flux profile and on insulin response in L6E9 myotubes at the metabolic level using a tracer-based metabolomic approach and our in-house developed software, Isodyn.
Results: Resistin significantly increased glucose uptake and glycolysis, altering pyruvate utilisation by the cell.