The effect of chronic hydrochlorothiazide administration on the composition of renal papillary interstitial fluid was investigated in the rat. Hydrochlorothiazide alone had no effect on papillary composition. However, when the sodium depletion that usually accompanies thiazide treatment was minimized by allowing the rats access to hypertonic NaCl solution, hydrochlorothiazide administration resulted in significant reductions in papillary osmolality, and sodium and potassium concentrations.
View Article and Find Full Text PDFPhys Rev A Gen Phys
September 1987
The influence of dietary potassium on the natriuretic effect of hydrochlorothiazide was investigated in conscious rats which had access to 0.46 M NaCl solution; the intake of saline was used as an index of the natriuresis. Control rats drank very little saline (less than 1 mmol 24 h-1), whereas animals given hydrochlorothiazide in the food (35 mg kg-1 dry weight) increased their saline intake to approximately 10 mmol 24 h-1.
View Article and Find Full Text PDFPhys Rev B Condens Matter
June 1987
Phys Rev A Gen Phys
February 1987
Phys Rev B Condens Matter
January 1987
Clin Sci (Lond)
April 1986
Hydrochlorothiazide was administered at two doses to Long-Evans rats for 7-10 days. Both doses resulted in an initial natriuresis and diuresis. After 1 day of treatment the natriuresis abated, but the diuresis persisted.
View Article and Find Full Text PDFPhys Rev B Condens Matter
February 1986
Phys Rev B Condens Matter
September 1985
Phys Rev B Condens Matter
August 1985