Publications by authors named "Shirley Cw Chan"
Objective: Systemic lupus erythematosus (SLE) is a heterogeneous disease which manifests as different subphenotypes. Distinct subphenotypes, such as lupus nephritis (LN), have been associated with increased genetic risk, but prior studies have been limited by cross-sectional and imprecisely subphenotyped cohorts. This study investigated the genetic basis for LN using a longitudinal cohort of distinctly subphenotyped patients.
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- This study compared the cardiovascular safety of three types of medications: interleukin-6 inhibitors (IL-6i), Janus Kinase inhibitors (JAKi), and tumour necrosis factor inhibitors (TNFi), in patients with rheumatoid arthritis (RA).
- Researchers analyzed data from Hong Kong, Taiwan, and Korea, focusing on newly diagnosed RA patients who started treatment with these drugs, tracking their health outcomes over time.
- The results showed no significant difference in the risk of cardiovascular events between patients taking IL-6i or JAKi compared to those taking TNFi, indicating similar safety profiles for these treatments across all three countries.