Publications by authors named "Shirin Smavadati"
Biochim Biophys Acta
December 2012
Article Synopsis
- Telomerase is primarily active in tumor cells, making it a target for cancer therapies; this study investigates imetelstat, a telomerase inhibitor, for treating esophageal cancer.
- Imetelstat was found to inhibit telomerase activity and reduce the colony formation ability of esophageal cancer cells within a week of treatment, while long-term use decreased cell growth based on telomere lengths.
- Short-term imetelstat treatment caused DNA damage markers in cancer cells, suggesting it may enhance the effects of radiation therapy by increasing DNA repair foci shortly after exposure.
