Publications by authors named "Shirin Navacci"
Aberrant activation of the Hedgehog (Hh) signalling pathway has been associated with the development and progression of pancreatic cancer. For this reason, blockade of Hh pathway by inhibitors targeting the G protein-coupled receptor Smoothened (SMO) has been considered as a therapeutic target for the treatment of this cancer. In our previous work, we obtained a new SMO ligand based on a purine scaffold (compound I), which showed interesting antitumor activity in several cancer cell lines.
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- The Sonic Hedgehog (SHH) pathway is vital for embryonic development, and its disruption can lead to medulloblastoma (MB), the most common brain tumor in children.
- Research shows that the transcription factor SALL4 is reactivated in SHH-MB, correlating with poorer survival outcomes for patients.
- SALL4 interacts with the tumor suppressor REN and is regulated by the CRL3 complex, indicating that targeting SALL4 could be a potential therapeutic strategy for treating SHH-dependent cancers.