Publications by authors named "Shirin Changizi"
Article Synopsis
- Atherosclerosis treatment often involves bypass surgery using veins or arteries, but graft compatibility issues can lead to the need for reoperation over time.* -
- This study tested the mechanical properties of human bypass grafts, specifically measuring their elastic modulus through uniaxial tensile testing and using the Mooney-Rivlin model for hyperelastic characteristics.* -
- Results showed that the saphenous vein has the highest stiffness among the tested grafts, which could improve clinical strategies for treating heart disease based on these mechanical properties.*
Carbon monoxide is a gasotransmitter that may be beneficial for vascular tissue engineering and regenerative medicine strategies because it can promote endothelial cell (EC) proliferation and migration by binding to heme-containing compounds within cells. For example, CO may be beneficial for vascular cognitive impairment and dementia because many patients' disrupted blood-brain barriers do not heal naturally. However, control of the CO dose is critical, and new controlled delivery methods need to be developed.
View Article and Find Full Text PDFEndothelialization of engineered vascular grafts for replacement of small-diameter coronary arteries remains a critical challenge. The ability for an acellular vascular graft to promote endothelial cell (EC) recruitment in the body would be very beneficial. This study investigated epsins as a target since they are involved in internalization of vascular endothelial growth factor receptor 2.
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