Publications by authors named "Shirani A"

Background: Although the benefits of low-level laser therapy (LLLT) in soft tissue healing have been demonstrated, the effects of laser on bone have remained controversial. This study investigated the impact of postoperative 660-nm LLLT on the radiographic crestal bone loss of fresh-socket dental implants.

Methods: Thirty patients referred to the Department of Oral and Maxillofacial Surgery for tooth extraction and placement of fresh-socket implants were selected and assigned to two groups: laser (intervention) and no-laser (control) groups.

View Article and Find Full Text PDF
Article Synopsis
  • Inflammation may play a significant role in epilepsy, especially in patients with multiple sclerosis (MS), who have higher seizure rates than the general population.
  • This study analyzed data from the FDA Adverse Event Reporting System to investigate the connections between MS treatments and the occurrence of epilepsy.
  • Results indicated that certain medications, particularly ibrutinib, showed an inverse association with epilepsy occurrences, suggesting they could be explored for new treatment options for epilepsy.
View Article and Find Full Text PDF

The differential diagnosis of suspected multiple sclerosis has been developed using data from North America, northern Europe, and Australasia, with a focus on White populations. People from minority ethnic and racial backgrounds in regions where prevalence of multiple sclerosis is high are more often negatively affected by social determinants of health, compared with White people in these regions. A better understanding of changing demographics, the clinical characteristics of people from minority ethnic or racial backgrounds, and the social challenges they face might facilitate equitable clinical approaches when considering a diagnosis of multiple sclerosis.

View Article and Find Full Text PDF
Article Synopsis
  • The study focuses on understanding the recurrence rate of colorectal polyps in average-risk individuals, emphasizing the importance of colorectal cancer (CRC) in the Middle East and the role of benign adenomas in its development.
  • A total of 237 patients were enrolled, with 102 completing a 3-year follow-up, revealing that a significant percentage developed adenomatous polyps, particularly those with a more complex morphology having a higher chance of recurrence.
  • The findings suggest the need for enhanced colonoscopy screening in areas previously deemed low-risk for CRC and recommend more frequent surveillance for patients showing dysplasia.
View Article and Find Full Text PDF

The basis of successful root canal therapy is the reduction of microorganisms. The aim of this in vitro study was to compare the antibacterial effect of three different irrigation methods with two laser wavelengths on biofilm. Ninety-five single-canal teeth were prepared, sterilized, and divided randomly into a negative control, a positive control, and five test groups.

View Article and Find Full Text PDF

Antiphospholipid syndrome is an immunopathologic disorder that should be considered in all patients with recurrent and/or unexplained thromboembolic events. Antiphospholipid antibodies are diagnostic markers, and anticoagulation therapy is the therapeutic and preventive strategy. Long-term anticoagulation therapy is necessary, with careful attention to potential bleeding complications.

View Article and Find Full Text PDF

Background: The presence of treatment-resistant microorganisms is known as the main cause of pulpectomy failure in the endodontic treatment of deciduous teeth. The usage of lasers can contribute to reducing these microorganisms. This study aimed to compare the effect of three disinfection methods for deciduous teeth canals using laser diode 810 nm, photodynamic therapy with laser 660 nm and methylene blue, and sodium hypochlorite.

View Article and Find Full Text PDF
Article Synopsis
  • Early childhood and adolescent obesity may increase the risk of developing multiple sclerosis (MS), as obesity can lead to inflammation that affects immune responses linked to MS.
  • This study aimed to investigate the relationship between weight-loss drugs and MS using data from the FDA's Adverse Event Reporting System (FAERS) over a nearly 20-year period.
  • Results showed that certain anti-diabetic weight-loss medications, like semaglutide and metformin, were associated with a lower likelihood of developing MS, while other weight-loss drugs did not show this protective effect.
View Article and Find Full Text PDF

Background: Case-based clinical reasoning (CBCR) is the proposed method to improve clinical reasoning. This brief report aimed to evaluate CBCR effectiveness to improve clinical reasoning via an online course.

Settings And Design: This study is a brief report of a before-after quasi-experimental study to evaluate CBCR in medical students of Shahid Beheshti University of Medical Sciences.

View Article and Find Full Text PDF
Article Synopsis
  • Pyogenic granuloma (PG) is a common growth in the mouth that can develop due to irritation, trauma, infection, or hormonal factors, mostly seen in young women but can affect anyone, including infants.
  • Treatment for PG usually involves surgical excision, but laser therapy is becoming a favored option due to its precision and less discomfort for patients.
  • This report highlights a case of an 11-month-old infant with a PG lesion in the palate, treated successfully with laser excision without any complications.
View Article and Find Full Text PDF

Introduction: For cell-based therapies of lung injury, several cell sources have been extensively studied. However, the potential of human fetal respiratory cells has not been systematically explored for this purpose. Here, we hypothesize that these cells could be one of the top sources and hence, we extensively updated the definition of their phenotype.

View Article and Find Full Text PDF

Depletion of circulating B lymphocytes using anti-CD20 monoclonal antibodies (mAbs) greatly reduces inflammatory activity in relapsing multiple sclerosis (RMS); it reduces progression to a lesser extent in nonrelapsing progressive MS. Mechanisms whereby anti-CD20 mAbs reduce MRI and clinical relapse activity in people with RMS are still being elucidated. Anti-CD20 agents do not fully protect from nonrelapsing disease progression, possibly due to their inability to cross the blood-brain barrier and inability to ameliorate the full extent of biology of MS progression.

View Article and Find Full Text PDF

Background: This study aimed to compare the effects of laser photodynamic therapy (PDT) with methylene blue (MB) or aminolevulinic acid (ALA) on the oral squamous cell carcinoma (OSCC) cell line.

Materials And Methods: In this experimental study, the C152 (KB) OSCC cell line was cultured in a culture medium containing 10% fetal bovine serum. The cells were exposed to 0.

View Article and Find Full Text PDF

A 56-year-old Caucasian man was diagnosed with definite neurosarcoidosis after he presented with progressive bilateral lower extremity weakness and dysesthesia. He was started on a combination immunosuppressant regimen of dexamethasone, methotrexate and infliximab. Two months into treatment with immunosuppressants, he developed devastating disseminated aspergillosis which clinically stabilized with aggressive antifungal treatment however had a protracted radiological course despite prolonged anti-fungal treatment for over two years.

View Article and Find Full Text PDF

High-contact stresses generated at the sliding interfaces during their relative movement provide a unique combination of local heating and shear- and load-induced compression conditions. These conditions, when involving the sliding of surfaces with certain material characteristics, may facilitate tribochemical reactions with the environment, leading to the formation of a protective, damage-suppressing tribofilm directly at the contact. Here, we employ the electrodeposition process to design a coating composed of a hard cobalt-phosphorous matrix with the inclusion of tribocatalytically-active nickel clusters.

View Article and Find Full Text PDF

Inhibiting the tribological failure of mechanical assemblies which rely on fuels for lubrication is an obstacle to maintaining the lifetime of these systems with low-viscosity and low-lubricity fuels. In the present study, a MoVN-Cu nanocomposite coating was tribologically evaluated for durability in high- and low-viscosity fuels as a function of temperature, load, and sliding velocity conditions. The results indicate that the MoVN-Cu coating is effective in decreasing wear and friction relative to an uncoated steel surface.

View Article and Find Full Text PDF

Background: Acute mesenteric ischemia (AMI) may present in COVID-19 patients without the classic risk factors of AMI, and the symptoms might confuse physicians, leading to delayed diagnosis and increased mortality. In this manuscript, we report a patient with COVID-19 who presented with AMI as its initial presenting symptom.

Case Presentation: A 68-year-old man presented to the emergency room with periumbilical non-radiating pain that had started three days before the admission.

View Article and Find Full Text PDF

Autoantibodies against nodal and paranodal proteins, specifically anti-neurofascin antibodies (ANFAs), have been recently described in central and peripheral nervous system demyelinating disorders. We retrospectively reviewed the charts of six individuals evaluated at our Multiple Sclerosis Program who tested positive for serum ANFAs on Western blot. We describe these patients' clinical and diagnostic findings and attempt to identify features that might guide clinicians in checking for ANFAs.

View Article and Find Full Text PDF

For the past four decades, multiple sclerosis (MS) has been a focus for clinical trial development and execution. Advances in translational neuroimmunology have led to the development of effective disease-modifying therapies (DMTs) that greatly benefit patients with MS and mitigate their burden of disease. These achievements also stem from continued progress made in the definition and discovery of sensitive disease diagnostic criteria, objective disability assessment scales, precise imaging techniques, and disease-specific biomarkers.

View Article and Find Full Text PDF
Article Synopsis
  • - A 48-year-old woman with multiple sclerosis (MS) developed red, raised skin lesions after long-term treatment with glatiramer acetate and Glatopa.
  • - A skin biopsy revealed a condition called lymphomatoid papulosis (LyP), a type of lymphoproliferative disorder.
  • - After discontinuing Glatopa, her skin lesions improved within three weeks, highlighting the need for awareness of skin issues in MS patients.
View Article and Find Full Text PDF

Minimizing the wear of the surfaces exposed to mechanical shear stresses is a critical challenge for maximizing the lifespan of rotary mechanical parts. In this study, we have discovered the anti-wear capability of a series of metal nitride-copper nanocomposite coatings tested in a liquid hydrocarbon environment. The results indicate substantial reduction of the wear in comparison to the uncoated steel substrate.

View Article and Find Full Text PDF

This data article presents the raw data used in the article "Experimental and analytical evaluation of exhaust air heat pumps in ventilation-based heating systems" [1]. The data set contains measurement results of a field monitoring on a residential exhaust air heat pump system (air-to-air heat pump) in Germany. This data could be used to investigate the dynamic behavior and performance of the exhaust air heat pump systems.

View Article and Find Full Text PDF