Publications by authors named "Shiran Gerassy"
Background: Acute myeloid leukemia (AML) is an aggressive hematological malignancy, associated with unfavorable patient outcome, primarily due to disease relapse. Mesenchymal stem cells (MSCs) residing in the bone marrow (BM) niche are the source of mesenchyma-derived subpopulations, including adipocytes, and osteocytes, that are critical for normal hematopoiesis. This study aimed to characterize BM-derived adipocyte/osteocyte fractions and their crosstalk with AML cells as a potential mechanism underlying leukemogenesis.
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- Therapeutic drug monitoring helps manage anti-TNF therapy in inflammatory bowel disease (IBD), but how drug levels relate in serum and tissue is not fully understood.
- The study analyzed samples from IBD patients treated with infliximab and adalimumab, revealing that free drug levels were higher in inflamed tissues and varied between the two medications.
- Results showed that serum drug levels (SDL) were linked to free drug in tissues, but the presence of TNF-drug complexes and anti-drug antibodies altered these dynamics, indicating a need for more research to optimize therapy.