Synopsis of recent research by authors named "Shiran Bar"
- Shiran Bar's research primarily focuses on the complex mechanisms of genomic imprinting and the regulation of gene expression in human pluripotent stem cells (hPSCs), exploring how parental contributions influence development and disease.
- Recent findings highlight the role of the HUSH complex in co-transcriptional genome surveillance, showcasing its ability to silence foreign DNA and distinguish between different classes of endogenous targets based on their epigenetic landscape.
- Bar's studies also emphasize the epigenetic aberrations in hPSCs, particularly in relation to parental imprinting and X chromosome inactivation, underlining the implications of these findings for therapies and understanding developmental processes.
