Publications by authors named "Shiraaz Gabriel"
Article Synopsis
- This study focuses on the use of noninvasive diagnostic methods to detect esophageal varices (EVs) in patients with compensated cirrhosis, contrasting with the traditional invasive method of upper endoscopy.
- Conducted on 50 patients at a hospital in Cape Town, the study analyzed various clinical and lab data, showing that 68% of participants had EVs, primarily caused by alcohol, hepatitis B, or autoimmune factors.
- Key findings emphasize significant differences in factors like liver and spleen stiffness, platelet counts, and dimensions that could enhance the accuracy of noninvasive tools for identifying EVs in patients.
Introduction: Tenofovir disoproxil fumarate (TDF) is widely recommended for treatment of chronic hepatitis B virus (HBV) infection because it is safe, affordable and has a high genetic barrier to resistance. TDF resistance associated mutations (RAMs) have been reported, but data are limited, particularly for Africa. We set out to identify potential RAMs in individuals with detectable HBV viraemia on TDF treatment.
View Article and Find Full Text PDFObjectives: Prompted by international targets for elimination of hepatitis B virus (HBV), we set out to characterise individuals with HBV monoinfection vs. those coinfected with HBV/HIV, to evaluate the impact of therapy and to guide improvements in clinical care.
Methods: We report observational data from a real world cross-sectional cohort of 115 adults with chronic hepatitis B infection (CHB), at a university hospital in Cape Town, South Africa.