Implications of Cheyne-Stokes breathing in advanced systolic heart failure.

Background: Cheyne-Stokes breathing (CSB) has been associated with heart failure (HF) patients for many years; however, its true prevalence and its prognostic implications are still obscure.

Hypothesis: The goal of this study was to investigate the prevalence and the possible prognostic implications of nocturnal CSB in advanced heart failure patients.

Methods: We performed single night full polysomonography ambulatory sleep studies in 71 HF patients.

Generation and analysis of a protein-protein interface data set with similar chemical and spatial patterns of interactions.

Protein-protein interfaces are regions between 2 polypeptide chains that are not covalently connected. Here, we have created a nonredundant interface data set generated from all 2-chain interfaces in the Protein Data Bank. This data set is unique, since it contains clusters of interfaces with similar shapes and spatial organization of chemical functional groups.