Publications by authors named "Shira Akov"
Article Synopsis
- Nijmegen breakage syndrome (NBS) is caused by a lack of the NBS1 protein, leading to issues like microcephaly, growth problems, immunodeficiency, and increased cancer risk.
- Researchers successfully reprogrammed NBS fibroblasts into induced pluripotent stem cells (NBS-iPSCs), although these cells showed chromosomal abnormalities and slower growth.
- The study highlights the crucial role of NBS1 in human development and reveals how cells handle genomic stress during reprogramming, with NBS neural progenitor cells (NBS-NPCs) showing reduced expression of neural developmental genes influenced by P53.
