Preparation and evaluation of Puerarin-loaded PLGA nanoparticles for improving oral bioavailability in SD rats.

Background: Puerarin (Pue) is an isoflavone compound with significant therapeutic effect on cardiovascular diseases, but its poor water solubility and low oral bioavailability limit clinical application.

Methods: In this study, Pue was prepared into PLGA nanoparticles (Pue-PLGA NPs) by emulsion solvent volatilization method. The morphology, particle size, Zeta potential, X-ray diffraction (XRD), and fourier transform infrared (FTIR) of the NPs were characterized.

Pressure-Induced Irreversible Metallization Accompanying Phase Transition of Chalcopyrite Cu(InGa)Se.

Chalcopyrite copper-indium-gallium diselenides (CIGS) have emerged as promising materials with remarkable electronic properties and potential applicability to high-efficiency solar cells. The crystal and electronic structures of CIGS can be continuously tuned from their initial states under pressure. Although pressure-induced band gap closure in CIGS has been predicted in extensive theoretical studies, it has not been supported by experimental evidence.

Polymer Nanoparticles with 2-HP-β-Cyclodextrin for Enhanced Retention of Uptake into HCE-T Cells.

Triamcinolone acetonide (TA), a medium-potency synthetic glucocorticoid, is primarily employed to treat posterior ocular diseases using vitreous injection. This study aimed to design novel ocular nanoformulation drug delivery systems using PLGA carriers to overcome the ocular drug delivery barrier and facilitate effective delivery into the ocular tissues after topical administration. The surface of the PLGA nanodelivery system was made hydrophilic (2-HP-β-CD) through an emulsified solvent volatilization method, followed by system characterization.

One-Step Hydrothermal Synthesis of Highly Fluorescent MoS Quantum Dots for Lead Ion Detection in Aqueous Solutions.

Lead ions in water are harmful to human health and ecosystems because of their high toxicity and nondegradability. It is important to explore effective fluorescence probes for Pb detection. In this work, surface-functionalized molybdenum disulfide quantum dots (MoS QDs) were prepared using a hydrothermal method, and ammonium tetrathiomolybdate and glutathione were used as precursors.

Pressure-induced phase transition in α- and β-BiNbO.

BiNbO has attracted a great deal of interest due to its excellent photocatalytic activities. Besides, it possesses rich polymorphism. Here, the structural stability and structural evolution of orthorhombic α- and triclinic β-BiNbO were investigated X-ray diffraction patterns and Raman spectra up to 46.

ReaxFF-MPNN machine learning potential: a combination of reactive force field and message passing neural networks.

Reactive force field (ReaxFF) is a powerful computational tool for exploring material properties. In this work, we proposed an enhanced reactive force field model, which uses message passing neural networks (MPNN) to compute the bond order and bond energies. MPNN are a variation of graph neural networks (GNN), which are derived from graph theory.