Electric polarization-enhanced optical thermometry in lanthanide ion-doped ferroelectric BiTiO nanosheets.

The demand for temperature measurement in optoelectronic integration has prompted research on advanced luminescent materials. Here, ferroelectric BiTiO:Yb/Er/Nd nanosheets were designed for optical thermometry. The transition emissions of nanosheets were significantly enhanced through electric polarization engineering.

Underwater Superoleophobic and Transparent Films with Mechanical Robustness and High Durability in Harsh Environments.

Underwater superoleophobic and transparent (UST) films are promising in applications, such as advanced optical devices in marine environments. However, the mechanical robustness and durability in harsh environments of the existing UST films are still unsatisfactory. In this work, we present a free-standing nacre-inspired mineralized UST (NIM-UST) film with high aragonite content and excellent mechanical properties toward robust underwater superoleophobicity on two surfaces and transparency (94%) in harsh seawater environments.

Circ_0000284 Is Involved in Arsenite-Induced Hepatic Insulin Resistance Through Blocking the Plasma Membrane Translocation of GLUT4 in Hepatocytes via IGF2BP2/PPAR-γ.

Arsenic exposure can induce liver insulin resistance (IR) and diabetes (DM), but the underlying mechanisms are not yet clear. Circular RNAs (circRNAs) are involved in the regulation of the onset of diabetes, especially in the progression of IR. This study aimed to investigate the role of circRNAs in arsenic-induced hepatic IR and its underlying mechanism.

Research on Off-Axis Integrated Cavity Output Spectrum Signal Denoising Based on CSGWO-SVMD-SVD method.

To mitigate the susceptibility of absorption lines to noise interference during gas measurement using the off-axis integrated cavity output spectroscopy (OA-ICOS) technique, thereby enhancing measurement accuracy, this paper introduces a novel denoising method. This method synergistically integrates Grey Wolf Optimization (GWO) and Cuckoo Search (CS) with Singular Value Decomposition (SVD) and Sequential Variational Mode Decomposition (SVMD). Initially, the optimal solution for the quadratic penalty coefficient in SVMD is ascertained via iterative optimization using the CSGWO algorithm.

The JNK signalling pathway gene BmJun is involved in the regulation of egg quality and production in the silkworm, Bombyx mori.

The Jun N-terminal kinase (JNK) signalling pathway has a key role in tissue remodelling during insect metamorphosis by regulating programmed cell death. However, multiple members of the JNK pathway in Lepidoptera remain uncharacterized. In this study, two key genes of the JNK pathway, BmJun and BmFos, were cloned from the silkworm Bombyx mori, a lepidopteran model insect, and their effects on reproductive development were investigated.

Prioritization of Eleven-Nineteen-Leukemia Inhibitors as Orally Available Drug Candidates for Acute Myeloid Leukemia.

Acute myeloid leukemia (AML) is the second most prevalent and fatal form of leukemia. The growth of AML cells harboring oncogenic MLL rearrangements relies on the YEATS domain-containing protein ENL. Many small molecule inhibitors targeting ENL have been developed.

Energy-Transfer-Enhanced Cr/Ni Co-doped Broadband Near-Infrared Phosphor for Fluorescence Thermometers and Near-Infrared Window Imaging.

Here, near-infrared broad dual-band emission phosphors were achieved through energy transfer between Cr and Ni ions in the β-GaO host. All samples co-doped with Cr and Ni exhibit dual-band emission covering 600-1700 nm under 430 nm excitation. Thanks to the doping of Cr ions, the emission intensity of GaO:Cr, Ni phosphors has increased by about 2.

Boosted Near-Infrared Photothermal Conversion in Rare Earth Ions-Doped 2D SnSe Nanosheets for Solar-Powered Water Evaporation Systems.

Solar-powered water evaporation as a clean and abundant renewable energy-efficient desalination technology provides a promising strategy to solve the shortage of freshwater resources. However, the development and application of solar vapor technology are hindered by the relatively low near-infrared photothermal conversion efficiency of existing materials and the lack of effective improvement strategies. In this work, the conductivity characteristics of 2D semiconductors are capitalized on the high visible light absorption and ultra-low thermal.

Research on optical performance of LnOS:Er/Yb (Ln = La/Gd/Y) phosphors based on different phonon energies.

It is crucial to explore the intrinsic mechanisms that influence thermometric sensitivity. This study investigates the optical performance of materials with the same crystal structure but different phonon energies. LnOS:Er/Yb (Ln = La/Gd/Y) phosphors with similar morphology and particle sizes were prepared to systematically study the influence of different phonon energy matrices on optical properties.

Preparation and Luminescence Properties of Broadband Orange-Emitting Persistent ScBaZnGaO:Bi Phosphor.

This article describes a new kind of afterglow material, ScBaZnGaO:Bi, which was synthesized through a high-temperature solid-phase method. Its crystal structure, photoluminescent characteristics, and afterglow characteristics were studied and analyzed. Upon excitation at 344 nm, ScBaZnGaO:Bi exhibits broadband emission with a central wavelength located at 571 nm (fwhm = 172.

Ultrasonic-driven degradation of organic pollutants using piezoelectric catalysts WS/BiWO heterojunction composites.

Water pollution has been made worse by the widespread use of organic dyes and their discharge, which has coincided with the industry's rapid development. Piezoelectric catalysis, as an effective wastewater purification method with promising applications, can enhance the catalyst activity by collecting tiny vibrations in nature and is not limited by sunlight. In this work, we designed and synthesized intriguing WS/BiWO heterojunction nanocomposites, investigated their shape, structure, and piezoelectric characteristics using a range of characterization techniques, and used ultrasound to accelerate the organic dye Rhodamine B (RhB) degradation in wastewater.

Antenna-based optimization of triplet radioluminescence of Tb-organic complex scintillator for efficient X-ray detection.

Triplet exciton is both a luminescence quenching factor and an important luminescence sensitization technology solution, which is widely concerned in the field of optoelectronic materials. Since X-ray excited triplet excitons are dissipated through various pathways, there are still huge difficulties in achieving efficient triplet sensitized emission. Here, the antenna ligand is regulated through the carboxyl group, increasing the steric hindrance between the conjugated groups and improving triplet-enhanced radioluminescence (RL) efficiencies of Tb.

Self-Powered and Self-Recovered Mechanoluminescent Electronic Skins for Detecting and Distinguishing Diverse External Stimuli.

The concept of simulating external mechanical stimuli to generate luminescence has been a long-standing aspiration in real-time dynamic visualization. However, creating self-power and self-restoring mechanoluminescent electronic skins for artificial sensors poses significant challenges. In this study, we introduce a cutting-edge triboelectric-mechanoluminescent electronic skin (TMES) that exhibits a remarkable response to multiple external stimuli.

Multi-Mode Luminescence in Smart Near-Infrared Cr/Pr Codoped SrGaO Phosphors Induced by Three Distinct Excitation Mechanisms.

Near-infrared (NIR) phosphors have emerged as novel luminescent materials across various fields due to their unique advantages of high penetration and invisibility. However, there is currently a lack of intelligent NIR phosphors that can achieve multimode stimuli responsive for sensing applications. In this study, we employed a high-temperature solid-phase reaction to incorporate Pr into Cr-doped gallate magnetite SrGaO phosphor, yielding a multimode luminescent intelligent NIR phosphor.

SARS-CoV-2 Main Protease Inhibitors That Leverage Unique Interactions with the Solvent Exposed S3 Site of the Enzyme.

The main protease (M) of SARS-CoV-2 is crucial for the virus's replication and pathogenicity. Its active site is characterized by four distinct pockets (S1, S2, S4, and S1-3') and a solvent-exposed S3 site for accommodating a protein substrate. During X-ray crystallographic analyses of M bound with dipeptide inhibitors containing a flexible -terminal group, we often observed an unexpected binding mode.

Multicolor tunable persistent luminescence mechanism in well-designed inorganic composites.

Herein, by ball milling CsPb(Br/I) quantum dot glass powder with SrMgSiO:Eu, Dy phosphor, multicolor tunable long persistent luminescence (LPL) in inorganic composites with more than 700 min attenuation time can be obtained via a radiation photon reabsorption process. Attractively, the wide color gamut of LPL spectra overlaps the National Television System Committee space 74%. Notably, the luminescence intensity remains stable when the inorganic composites are composed with UV light for 100 h.

The circadian clock affects starvation resistance through the pentose phosphate pathway in silkworm, Bombyx mori.

Disruption of the circadian clock can affect starvation resistance, but the molecular mechanism is still unclear. Here, we found that starvation resistance was significantly reduced in the core gene BmPer deficient mutant silkworms (Per), but the mutant's starvation resistance increased with larval age. Under natural physiological conditions, the weight of mutant 5th instar larvae was significantly increased compared to wild type, and the accumulation ability of triglycerides and glycogen in the fat bodies was upregulated.

Leveraging a Phage-Encoded Noncanonical Amino Acid: A Novel Pathway to Potent and Selective Epigenetic Reader Protein Inhibitors.

Epigenetic reader proteins interpret histone epigenetic marks to regulate gene expression. Given their vital roles and the link between their dysfunction and various diseases, these proteins present compelling targets for therapeutic interventions. Nevertheless, designing selective inhibitors for these proteins poses significant challenges, primarily due to their unique properties such as shallow binding sites and similarities with homologous proteins.

Structural Causes of Brittleness Changes in Aluminosilicate Glasses with Different Cooling Rates.

Numerous sources have already demonstrated that varying annealing rates can result in distinct toughness and brittleness in glass. To determine the underlying mechanisms driving this phenomenon, molecular dynamic (MD) simulations were employed to investigate the microstructure of aluminosilicate glasses under different cooling rates, and then uniaxial stretching was performed on them under controlled conditions. Results indicated that compared with short-range structure, cooling rate has a greater influence on the medium-range structure in glass, and it remarkably affects the volume of voids.

Bruceantinol works as a CDK2/4/6 inhibitor to inhibit the growth of breast cancer cells.

Bruceantinol (BOL), isolated from the dried fruit of the Brucea javanica (L.) Merr., exhibits cytotoxic effects on breast cancer cells.

Discovery of First-in-Class PROTAC Degraders of SARS-CoV-2 Main Protease.

We have witnessed three coronavirus (CoV) outbreaks in the past two decades, including the COVID-19 pandemic caused by SARS-CoV-2. Main protease (M), a highly conserved protease among various CoVs, is essential for viral replication and pathogenesis, making it a prime target for antiviral drug development. Here, we leverage proteolysis targeting chimera (PROTAC) technology to develop a new class of small-molecule antivirals that induce the degradation of SARS-CoV-2 M.

Azapeptides with unique covalent warheads as SARS-CoV-2 main protease inhibitors.

The main protease (M) of SARS-CoV-2, the causative agent of COVID-19, is a pivotal nonstructural protein critical for viral replication and pathogenesis. Its protease function relies on three active site pockets for substrate recognition and a catalytic cysteine for enzymatic activity. To develop potential SARS-CoV-2 antivirals, we successfully synthesized a diverse range of azapeptide inhibitors with various covalent warheads to target M's catalytic cysteine.

Efficient Solar-Driven Interfacial Water Evaporator using Hydrogel Modified Carbon-Based Biomass with Abundant Microchannels.

The conventional sea water desalination technologies are not yet adopted worldwide, especially in the third world countries due to their high capital cost as well as large energy requirement. To solve this issue in a sustainable way an interfacial solar water evaporation device is designed and proposed in this article using the branches of Prunus serrulata (PB). The PB has abundant microchannels and shows excellent photothermal conversion capability after carbonization.

Effects of Habitual Dietary Change on the Gut Microbiota and Health of Silkworms.

Diet plays a crucial role in shaping the gut microbiota and overall health of animals. Traditionally, silkworms are fed fresh mulberry leaves, and artificial diets do not support good health. The aim of this study was to explore the relationship between the dietary transition from artificial diets to mulberry leaves and the effects on the gut microbiota and physiological changes in silkworms as a model organism.

BRD4354 Is a Potent Covalent Inhibitor against the SARS-CoV-2 Main Protease.

Numerous organic molecules are known to inhibit the main protease (M) of SARS-CoV-2, the pathogen of Coronavirus Disease 2019 (COVID-19). Guided by previous research on zinc-ligand inhibitors of M and zinc-dependent histone deacetylases (HDACs), we identified BRD4354 as a potent inhibitor of M. The protease activity assays show that BRD4354 displays time-dependent inhibition against M with an IC (concentration that inhibits activity by 50%) of 0.